Supplementary Information Available The mechanism of aquaporin inhibition by gold compounds elucidated by biophysical and computational methods Andreia de Almeida, a,† Andreia F. Mósca, b,c,† Darren Wragg, a Margot Wenzel, a Paul Kavanagh, d Giampaolo Barone, e Stefano Leoni, a Graça Soveral, b,c * Angela Casini 1 * a School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom. b Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal. c Dept. Bioquímica e Biologia Humana, Faculty of Pharmacy, Universidade de Lisboa, 1649-003 Lisboa, Portugal d School of Chemistry and Chemical Engineering, Queen’s University Belfast, David Keir Building, Stranmillis Road, Belfast, BT9 5AG, United Kingdom. e Dip. di Scienze e Tecnologie Biologiche, Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Viale delle Scienze Ed. 17, 90128, Palermo, Italy. 1 Electronic Supplementary Material (ESI) for ChemComm. This journal is © The Royal Society of Chemistry 2017