Brief report Impact of perioperative glycaemia and glycated haemoglobin on the outcomes of the surgical treatment of diabetic foot osteomyelitis Javier Arago ´ n-Sa ´ nchez a, *, Jose ´ Luis La ´ zaro-Martı ´nez b a Diabetic Foot Unit, La Paloma Hospital, Las Palmas de Gran Canaria, Spain b Diabetic Foot Unit, Complutense University Clinic, Madrid, Spain 1. Introduction The association between hyperglycaemia and the increased risk of complications and mortality in patients with diabetes undergoing general, vascular and cardiac surgery have previously been reported [1]. Poor metabolic control was shown to be a predictor of amputation in patients hospitalised for diabetic foot ulcers [2]. Osteomyelitis is one of the most frequent diabetic foot infections and one of the usual approaches is surgery. The influence of glycaemic control on the outcomes of surgery for osteomyelitis has not been previously reported in a prospective way. Our aim was to investigate whether or not perioperative glycaemia had any influence on the outcomes of surgical treatment of diabetic foot osteomyelitis. 2. Methods From 1 November 2007 to 30 May 2010, we enrolled a prospective cohort of patients with diabetes who underwent surgical treatment for osteomyelitis. Osteomyelitis was diag- nosed based on probing-to-bone tests and radiological studies of the foot. Peripheral arterial disease was diagnosed if the patient met the following criteria: absence of both distal pulses and/or an ankle brachial index below 0.9. Pre-meal d i a b e t e s r e s e a r c h a n d c l i n i c a l p r a c t i c e 9 4 ( 2 0 1 1 ) e 8 3 – e 8 5 a r t i c l e i n f o Article history: Received 4 September 2011 Accepted 6 September 2011 Published on line 28 September 2011 Keywords: Diabetic foot Osteomyelitis Diabetic foot infection Foot ulcer Lower extremity amputation Peripheral arterial disease a b s t r a c t Perioperative glycaemic control during admission was a predictive factor of amputation in a prospective cohort of 81 patients with diabetes who underwent surgical treatment for osteomyelitis. Glycaemic control before admission, as determined by glycosylated haemo- globin, did not have any influence on the outcomes. # 2011 Elsevier Ireland Ltd. All rights reserved. * Corresponding author at: C/Eduardo 1,48D, 35002 Las Palmas de Gran Canaria, Canary Islands, Spain. Tel.: +34 928383161; mobile: +34 609569937. E-mail addresses: javiaragon@telefonica.net, draragon@piediabetico.net (J. Arago ´ n-Sa ´ nchez). Contents available at Sciverse ScienceDirect Diabetes Research and Clinical Practice journal homepage: www.elsevier.com/locate/diabres 0168-8227/$ – see front matter # 2011 Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.diabres.2011.09.009