Passerini three-component cascade reactions in deep eutectic solvent: an environmentally benign and rapid system for the synthesis of a-acyloxyamides Ahmad Shaabani 1 • Ronak Afshari 1 • Seyyed Emad Hooshmand 1 Received: 30 August 2015 / Accepted: 11 December 2015 Ó Springer Science+Business Media Dordrecht 2015 Abstract A greener synthesis of a-acyloxyamides was achieved by one-pot three component cascade Passerini reactions in a deep eutectic solvent (DES). Reactions proceeded rapidly and afforded the corresponding a-acyloxyamides by a variety of aldehydes, acids and isocyanides in excellent yields. The DES has the advantages of easy workup, high yield, and an environmentally benign and, moreover, shortened time as the greatest exclusivity of this system compared with previously reported methods. Graphical Abstract Passerini three-component cascade reaction in a deep eutectic solvent: an environmentally benign and rapid system for the synthesis of a-acyloxyamides. & Ahmad Shaabani a-shaabani@sbu.ac.ir 1 Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran 123 Res Chem Intermed DOI 10.1007/s11164-015-2390-x