ACCEPTED MANUSCRIPT ACCEPTED MANUSCRIPT 1 Nrf2 targeting by sulforaphane: a potential therapy for cancer treatment Maria Russo 1* , Carmela Spagnuolo 1* , Gian Luigi Russo 1* , Krystyna Skalicka-Woźniak 2 , Maria Daglia 3 , Eduardo Sobarzo-Sánchez 4 , Seyed Fazel Nabavi 5 , Seyed Mohammad Nabavi 5* 1. Institute of Food Sciences, National Research Council, 83100, Avellino, Italy 2. Department of Pharmacognosy with Medicinal Plants Unit, Medical University of Lublin, Lublin, Poland 3. Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy 4. Laboratory of Pharmaceutical Chemistry, Department of Organic Chemistry, Faculty of Pharmacy, University of Santiago de Compostela, 15782, Spain 5. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran * Equal contribution Corresponding authors: Gian Luigi Russo, email: glrusso@isa.cnr.it Seyed Mohammad Nabavi, email: nabavi208@gmail.com Abstract