THU283 GFR reset point at 3 months after liver transplant is a superior predictor of liver and kidney disease related outcomes: analysis from a large cohort of NASH patients (nail NASH consortium) Sanjaya Satapathy 1,2 , Yu Jiang 3 , Masahiko Yazawa 4 , Miklos Z. Molnar 5 , Tandy Agostini 6 , Raiya Sarwar 7 , Carlos Figueredo 8 , Daniel Maluf 5 , Saleh Elwir 9 , James F. Trotter 9 , Arul Thomas 10 , Coleman I. Smith, MD 10 , Danielle Brandman 11 , Mohammad Siddiqui 12 , Kymberly Watt 13 , Mary Rinella 14 . 1 North Shore University Hospital, Manhasset, United States; 2 Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Medicine, Hempstead, United States; 3 University of Memphis, Public Health, Memphis, United States; 4 Methodist University Hospital, Surgery, Memphis, United States; 5 Methodist University Hospital, Suregry, Memphis, United States; 6 MedStar Georgetown Transplant Institute in Annapolis, Annapolis, United States; 7 University of Minnesota, Gastroenterology, Minneapolis, United States; 8 Montefiore Medical Center Moses Division, United States; 9 Baylor University Medical Center, Part of Baylor Scott & White Health, Dallas, United States; 10 MedStar Georgetown University Hospital, Washington, United States; 11 UCSF Medical Center, San Francisco, United States; 12 VCU Medical Center, Richmond, United States; 13 Mayo Clinic, Scottsdale, United States; 14 Northwestern Medicine Digestive Health Center Lavin Family Pavilion, Chicago, United States Email: sanjaya.satapathy@yahoo.com Background and Aims: Since the introduction of the MELD score increasing number of patients with renal failure is being trans- planted. The evolution of renal function based on the on severity of renal dysfunction at the time of LT is unclear inpatients with NASH. We examined, (1) the association of pretransplant renaldysfunction (eGFR closet to LT) with the slope of renal function after LT, (2) incident CKD events after LT, (3) time to progression to CKD after LT and (3) all-cause mortality after LT. Method: From the NailNASH consortium data set, we identified 696 NASH recipients who received deceased donor LT. Recipients were analyzed in 3 groups: Low GFR (LGFR) (estimated glomerular filtration rate (eGFR) <30 mL/minute/1.73 m 2 at LT; n = 108); High GFR (HGFR) (eGFR ≥ 30 mL/minute/1.73 m 2 ; n = 483); and those with SLKT (n = 105). The longitudinal data set with eGFR at transplant (0) and 3, 6,12, 24, 36, 48, and 60 months post-LT. CKD was defined as two eGFR levels <30 mL/min/1.73 m 2 separated by ≥90 days. Figure 1: Spaghetti Plot of estimated GFR over 12 months. Figure 2: Spaghetti Plot of estimated GFR over 60 months. Results: Mean age at LT was 60 ±9 years, 49% male, 74% Caucasian. We censored follow up at 5 years. Figure 1 and 2 represents the eGFR over time by group (over 12 months, and over 60 months respectively) with mean eGFR over time (red line). A statistically significant change in the slope for eGFR at 3 months after LT was noted in all three groups, called as “GFR reset point.” The difference between the eGFR slope before 3 months and after 3 months estimated by linear mixed-effects model was significant in all 3 groups (p < 0.0001). Overall unadjusted incident CKD rate was 21.3/ 1000 patient-years (95%CI: 16.7–25.9). The unadjusted incident CKD ratewas significantly higher among patients in the LGFR group (crude incident CKD rate: 48.1/1000 patient-years (95%CI: 32.0–64.3) compared to patients with HGFR (crude incident CKD rate: 15.7/ 1000 patient-years (95% CI: 10.9–20.5; p < 0.0001) after Bonferroni correction for multiple testing, but not significantly different compared to SLKT group (crude incident CKD rate: 19.1/1000 patient-years (95%CI: 7.–30.3; p = 0.57). Time to CKD event analysis using Kaplan-Meier curves showed a significantly increased risk of progression to CKD in the LGFR group using either preLT GFR (p < 0.0001) or the 3-month post LT reset point (p = 0.05) as the baseline. Additionally, LGFR group had worse overall patient survival using the 3 month “reset point” point as the baseline (P < 0.0001). Conclusion: In a large multicenter cohort of LT recipients with NASH, grouped by severity of renal dysfunction at the preLT period, a statistically significant change in the slope for eGFR at 3 months after LT (GFR reset point) was noted. Long term liver and kidney disease outcome appears to be modified by this new baseline. LGFR group had increased risk for progression to CKD as well as overall mortality. THU284 Is hepatitis B immunoglobulin necessary for hepatitis D prophylaxis after liver transplantation? A retrospective multicenter studyof a cohort of 174 patients Sergio Rodríguez-Tajes 1,2 , María García Eliz 3 , Arantxa Caballero 4 , Isabel Campos-Varela 5 , Alba Cachero 6 , Carmelo Loinaz-Segurola 7 , Miguel Angel Gómez-Bravo 8 , Manuel Rodríguez-Perálvarez 2,9 , Emilio Fabrega 10 , Maria Luisa Gonzalez Dieguez 11 , Carmen Viaixa 3 , Juan Manuel Pascasio 2,8 , Inmaculada Fernández Vázquez 7 , Carme Baliellas 6 , Lluis Castells 2,5 , Magdalena Salcedo 4 , Martin Prieto 3 , Miguel Navasa 1,2 , Xavier Forns 1,2 . 1 Hospital Clínic de Barcelona, IDIBAPS, Liver Unit, Barcelona, Spain; 2 Ciberehd; 3 Hospital Universitario y Politécnico de La Fe, Liver Unit, Valè ncia, Spain; 4 Gregorio Marañón Hospital, Liver transplant Unit, Madrid, Spain; 5 Vall d’Hebron University Hospital, Liver Unit, Barcelona, Spain; 6 Bellvitge University Hospital, Liver Unit, L’Hospitalet de Llobregat, Spain; 7 University Hospital 12 de Octubre, Liver Transplant Unit, Madrid, Spain; 8 Virgen del Rocio Hospital, Sevilla, Spain; 9 Hospital Universitario Reina Sofia, Córdoba, Spain; 10 Marqués de Valdecilla University Hospital, Liver Unit, POSTER PRESENTATIONS S278 Journal of Hepatology 2020 vol. 73 | S123–S400