Objective: To examine the motor skills of patients after stroke about visuomotor learning. Design: A case-control study. Setting: A rehabilitation center. Participants: The subjects were 14 healthy people (the control group: mean  SD, 43.4.1 years, 7 men and 7 women), and 14 patients with right brain damage (the right brain damage group: mean  SD, 49.55.6 years, 9 men and 5 women), and 14 patients with left brain damage (the left brain damage group: mean  SD, 46.35.0 years, 7 men and 7 women). Interventions: We used a computerized motor skill ana- lyzer (CMSA) for the lower limb that can evaluate the speed and the accuracy of movements in tracking tasks. The sub- jects were instructed to draw a figure-eight on the display with their foot, as quickly and accurately as possible. Proce- dures of practice and measurement of motor learning were as follows: (1) 10 measurement trials in the morning of the first day, (2) 10 trials of the mirror image task was applied immediately after the first measurement, (3) 10 measurement trials at 5-7 hours later, and (4) 10 measurement trials the next morning. Main Outcome Measures: Lap time and integrated distance over the time of the normal task. Results: Although the motor skills of the control group and the left brain damage group were improved the next morning, the right brain damage group did not show improvement. Conclusions: Our results suggest that the motor skill learning of patients with right brain damage are reduced by the visuomotor interference task, because the visuomotor skills in patients with right brain damage are more disabled than in patients with left brain damage. Poster 434 A Survey of Constipation in Acute Stroke Patients. Jin Hwa Yi (Asan Medical Center, Seoul, Republic of Korea); Min Ho Chun. Disclosures: J. Yi, None. Objective: To investigate the risk factors of constipation and to evaluate colon motility patterns in acute stroke pa- tients. Design: Case control study. Setting: Tertiary medical center. Participants: 51 subjects are classified as constipation (n=25) and nonconstipation group (n=26). Interventions: Consciousness, ambulation distance, Ko- rean version of Modified Bathel Index (K-MBI), water and food intake, urine output, voiding dysfunction, combined dysphagia and depression and use of medications were eval- uated as risk factors for constipation. The colon transit time (CTT) of was measured using radiopaque markers for the ascending (aCTT), descending (dCTT), rectosigmoid (rsCTT) colons as well as for the entire colon (tCTT). Main Outcome Measures: APECS score of ambulation distance (from 1 for “needs maximal assistance from 2 people or an assistive device +1 person” to 7 for “within normal limits, functionally independent”) and CTT uses hour. Results: The APEC score and the K-MBI scores of the pa- tients with constipation was significantly lower than those of the patients without constipation (P.01). There were more patients that had dysphagia in the constipation group com- pared with the other group (P.05). However, there were no significant differences in the other parameters between both groups. The aCTT, dCTT and tCTT in the constipa- tion patients were significantly delayed (aCTT: 18.615.8 versus 5.37.3, dCTT: 19.313.7 versus 5.95.5, tCTT: 50.318.8 versus 22.216.4, P.05). There was no signif- icant difference in rsCTT (12.311.5 versus 10.910.3) between the 2 groups. Conclusions: This study shows that new occurrences of constipation in poststroke patients are associated with poor functional state and dysphagia. Considering these factors, we should establish more intensive bowel management pro- grams for stroke patients with poor functional state and dysphagia. Colon motility patterns in stroke patients with new onset constipation are delayed in the colon, especially in the ascending and descending colon. Poster 435 A UK Pilot for a Large International Prospective Cohort Analysis of the Use of Botulinum Toxin A (BoNT-A) in Upper Limb Spasticity. Lynne F. Turner-Stokes, DM FRCP (King's College London, London, United Kingdom); Stephen Ashford, BSc (Hons), MSc, PGCE; Heather Williams, MSc. Disclosures: L. F. Turner-Stokes, Northwick Park Hos- pital,EmploymentBSKing’s College London,Employment- BSDunhill Medical Trust,Research grantsLuff Foundation, Research grants National Institute for Health Research (UK), Research grants Ipsen,Consulting fees or other remunera- tionAllergan,Consulting fees or other remuneration. Objective: (a) To examine routine clinical practice in the use of BoNT-A for upper limb spasticity in the UK, (b) to identify the commonly used methods for clinic-based docu- mentation, follow-up and outcome evaluation, (c) to pilot a preliminary case report proforma for future use in a large international prospective cohort study. Design: A multicenter noninterventional prospective co- hort analysis. Setting: Twelve UK centers providing BoNT-A injections as part of an established spasticity management program. Participants: Adults receiving routine planned treatment for upper limb spasticity. Of 151 enrolled, 129 (85%) com- S190 PRESENTATIONS