Special Issue 1, 2022 Indian Journal of Pharmaceutical Sciences Review Article 235 *Address for correspondence E-mail: yunus.tatagar@gmail.com Yunus Khan et al.: Convalescent Plasma Therapy-A Treatment of Choice for COVID-19 The severe acute respiratory syndrome coronavirus 2 which is the source of pandemic coronavirus disease 2019 has engulfed almost whole world. This virus was frst reported in Wuhan city (China) in December 2019. Since the discovery of the virus, till today the researchers and scientists have been working to develop new vaccines or therapeutic agents against severe acute respiratory syndrome coronavirus 2. However, thus far no vaccine has emerged that can be approved to treat or prevent coronavirus disease 2019. Due to lack of specifc preventative and therapeutic options for the treatment of coronavirus disease 2019, the use of convalescent plasma therapy may be of great beneft in the current situation. Previous use of immune plasma has resulted in successful treatment of hemagglutinin type 1 and neuraminidase type 1 infuenza virus, Middle East respiratory syndrome coronavirus and severe acute respiratory syndrome coronavirus 1 epidemics. In the current scenario raised by coronavirus disease 2019, the convalescent plasma therapy has been applied successfully among many patients across various regions. This article presents an up-to-date review of existing literature on recovery through convalescent plasma as a treatment of choice, safety and its efcacy, possibility and its challenges for the treatment of coronavirus disease 2019. Key words: Coronavirus disease 2019, convalescent plasma therapy, severe acute respiratory syndrome coronavirus 2 The Coronavirus Disease 2019 (COVID-19) pandemic infected more than 244 million people with 221 million recoveries and 4 953 017 deaths worldwide till 25 th October 2021 [1] . The virus has spread throughout the globe and hence it has been declared a pandemic by the World Health Organization (WHO) [2,3] . The most afected countries being United States of America (USA), India and Brazil with a caseload of more than 46, 34 and 21 million infections respectively by 25 th October 2021, with many other countries having substantial infections. This pandemic has impacted all public and private sectors which have led to global socio-economic devastation [4] . The world has responded to this crisis with resilience and determination [5] . As of today, there is no prescribed vaccine to fght the coronavirus infection, though the research and eforts to develop a vaccine are going on war footage. It must be borne in mind that the development of any vaccine is a lengthy process that needs to be followed to ensure the safety and efcacy to treat the given disease. However, the current pandemic has spread in such a short span of time that the world is forced to depend on whatever alternate treatment methods are available until a safe vaccine is developed. Therefore, countries around the world have limited options to tackle this pandemic infection. Governments implemented lockdown, instructed to maintain strict social and physical distancing, cut trade and travels, employees were asked to stay at home or work from home, educational institutions were closed to break the chain of the infection. This method has been found efective in controlling the confrmed cases and death Convalescent Plasma Therapy: A Treatment of Choice for COVID-19 during Current Pandemic T. M. YUNUS KHAN*, I. A. BADRUDDIN, S. A. SAQUIB 1 , R. MOHAMED 2 , S. ARORA 3 , M. A. K. MOHAMMED 3 , S. V. SHAMSUDDIN 4 , S. KHATEEB 3 , A. A. KHAN 5 , V. GROVER 6 AND PRIYANKA SALUJA 7 Department of Mechanical Engineering, College of Engineering, 1 Department of Periodontics and Community Dental Sciences, College of Dentistry, King Khalid University, Abha 61421, 2 Department of Pharmaceutics, College of Pharmacy, King Khalid University, Guraiger, Abha 62529, 3 Department of Restorative Dentistry, College of Dentistry, 4 Department of Orthodontics, 5 Department of Oral Surgery, College of Dentistry, King Khalid University, Abha 61421, Kingdom of Saudi Arabia, 6 Department of Periodontology and Implantology, Dr. Harvansh Singh Judge Institute of Dental Sciences, Chandigarh 160014, 7 Department of Conservative Dentistry and Endodontics, Jan Nayak Choudhary Devi Dental College, Sirsa, Haryana 125055, India