530 Jpn J Ophthalmol Vol 47: 529–531, 2003 Figure 1. Patient 3. Slit-lamp view of the right eye shows clear corneal graft 2 months after autograft keratoplasty using a 0.5- mm larger button harvested from the patient’s blind left eye. Figure 2. Patient 3. Slit-lamp view of the blind left eye shows opacity and edema of the allograft of preserved frozen cornea, 0.5 mm larger in diameter than the corneal window, 2 months after placement of the graft. Correspondence to: Masahiko Fukuda, MD, PhD, Department of Oph- thalmology, Kinki University School of Medicine, 377-2, Ohno-Hi- gashi, Osaka-Sayama City, Osaka, Japan. doi:10.1016/S0021-5155(03)00107-2 References 1. Barraquer J. Reconstruction of the anterior segment of the eye by autokeratoplasty: report of a case. Trans Am Acad Ophthalmol Otola- ryngol 1971;75:1245–1250. 2. Yamaguchi T, Nakajima A, Kanai A, et al. Autokeratoplasty. Nippon Ganka Gakkai Zasshi (Acta Soc Ophthalmol Jpn) 1978;82:449–456. 3. Hodkin MJ, Insler MS. Transplantation of corneal tissue from a blinded eye to a high-risk fellow eye by bilateral penetrating ker- atoplasty. Am J Ophthalmol 1994;117:808–809. 4. Sugar J. Phakic keratoplasty. In: Brightbill FS, ed. Corneal surgery. St Louis: Mosby, 1999:279–283. 5. Matsuda M, Manabe R. The corneal endothelium following autokera- toplasty. A case report. Acta Ophthalmol 1988;66:54–57. Acute Angle-closure Glaucoma Associated with Latanoprost Latanoprost (Xalatan; Pharmacia & Upjohn, Kalama- zoo, MI, USA) is a prostaglandin F 2α analogue that was introduced as an ocular hypotensive agent for patients with open-angle glaucoma and ocular hypertension. Side ef- fects associated with latanoprost include conjunctival hy- peremia, increased iris pigmentation, anterior uveitis, cystoid macular edema, and reactivation of herpes sim- plex keratitis. 1 We report 2 cases with a history of angle-closure glau- coma that demonstrated acute congestive angle-closure glaucoma in association with the topical administration of latanoprost. Case Reports Case 1. In 1998, a 69-year-old woman with a 10- year history of primary angle-closure glaucoma under- went Nd:YAG laser iridotomy after an acute attack of angle-closure glaucoma in the left eye. She refused laser iridotomy treatment in the right eye. Subsequently, be- cause the patient was going to travel from our district and could not be under our care, we prescribed medication of topical timolol maleate 0.50% for both eyes. Due to the patient’s cardiac problems, this topical medication was discontinued and latanoprost 0.005% treatment was initiated to both eyes by another physician. In September 2000, after 3 days of latanoprost therapy the patient re- turned to our clinic with symptoms of redness and pain only in her right eye. Intraocular pressure (IOP) was 52 mm Hg OD and 17 mm Hg OS. Slit-lamp biomicroscopy revealed corneal edema, shallow anterior chamber with extensive iridocorneal contact, and fixed mid-dilated pu- pilla in her right eye. The left eye was totally normal with an open peripheral iridotomy. Acute attack of angle- closure glaucoma was diagnosed in her right eye. Because latanoprost was considered a possible cause of this acute angle-closure glaucoma, the drug was discon- tinued, and treatment was started with timolol maleate 0.50% 2 × 1, pilocarpine hydrochloride 4% 4 × 1 every 15 minutes and later 4 × 1/day, acetozolamide hydrochloride 250 mg tablets 4 × 1, and mannitol 20% 1 g/kg. On the next day, IOP was 14 mm Hg in the right eye and 16 mm Hg in the left eye. Corneal edema had diminished, the anterior chamber was deep, and pupilla were miotic in the right eye. Nd:YAG laser iridotomy was performed on the right eye. Latanoprost treatment was not resumed and the patient continued on only timolol maleate 0.50% 2 × 1 in both eyes. Within the 20 months of follow-up, there have been no symptoms of IOP elevation.