Journal Pre-proofs Thermosensitive and Biodegradable Hydrogel Encapsulating Targeted Nano- particles for the Sustained Co-Delivery of Gemcitabine and Paclitaxel to Pan- creatic Cancer Cells Ahmed M. Shabana, Siva P. Kambhampati, Ru-ching Hsian, Rangaramanujam M. Kannan, Efrosini Kokkoli PII: S0378-5173(20)31124-8 DOI: https://doi.org/10.1016/j.ijpharm.2020.120139 Reference: IJP 120139 To appear in: International Journal of Pharmaceutics Received Date: 21 July 2020 Revised Date: 23 November 2020 Accepted Date: 27 November 2020 Please cite this article as: A.M. Shabana, S.P. Kambhampati, R-c. Hsian, R.M. Kannan, E. Kokkoli, Thermosensitive and Biodegradable Hydrogel Encapsulating Targeted Nanoparticles for the Sustained Co- Delivery of Gemcitabine and Paclitaxel to Pancreatic Cancer Cells, International Journal of Pharmaceutics (2020), doi: https://doi.org/10.1016/j.ijpharm.2020.120139 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier B.V.