modelled in two ways: 1) HG vs. non-HG men 2) treated vs. untreated HG men. We stratified primary or revision implant status in both models. RESULTS: We identified 17,067 men who received a penile implant of which 4923 had a diagnosis of HG. The average age of the non-HG and HG cohort was 62.8 yrs (SD:9.6) and 61.3 yrs (SD:9.3), respectively. The time from penile prosthesis implantation to time of prosthesis infection stratified by HG status is shown in Figure 1. The median time to prosthesis infection was 99 days (Range: 1-2696). Men with HG had a higher rate of infection (HR:1.25, 95% CI:1.02- 1.53, p[0.035) compared to men without HG. In treated HG men (n [2048) who underwent penile implant, there was no difference in the rates of infection (HR:1.19, 95% CI:0.71-1.99) when compared to men without HG. CONCLUSIONS: In this national claims-based study, untreated HG independently increases the rate of infection after penile prosthetic surgery. In HG men who receive testosterone therapy, this effect is ameliorated. Further prospective studies are needed to validate these findings. Source of Funding: None MP57-16 IMMEDIATE SALVAGE WITH INFLATABLE PENILE PROSTHESIS IN AN INFECTED FIELD: A CONTEMPORARY MULTI-INSTITUTIONAL COHORT Daniel Jiang*, John Barnard, Edward Choi, Orange, CA; James Furr, Oklahoma City, OK; Aaron Lentz, Durham, NC; Koenraad van Renterghem, Hasselt, Belgium; Patrick Selph, Birmingham, AL; Faysal A. Yafi, Orange, CA INTRODUCTION AND OBJECTIVE: Contemporary manage- ment of inflatable penile prosthesis (IPP) infections involves removal and replacement to minimize corporal fibrosis and penile shortening. Many urologists prefer a malleable prosthesis (MP) followed by staged conversion to IPP, a technique thought to improve outcomes by allowing treatment of the infection while maintaining intracorporeal volume. A staged procedure involves additional surgery with associated risks. Previous studies suggest an 18% infection risk of placing a sec- ond device in a non-infected, revision setting, and that infection risk increases with each subsequent procedure. Our study aims to delineate whether immediate IPP salvage in an infected field yields similar complication rates to the staged approach. METHODS: Retrospective review at 5 different institutions from February 2010 to October 2020 identified patients with IPP infection who underwent IPP salvage. Patient demographic, laboratory, opera- tive, and microbiology data were collected. Emphasis was placed on the salvage operative technique, duration of antibiotics, and post-salvage complications. RESULTS: Overall, 19 patients underwent immediate salvage with IPP in the setting of a suspected infection. Average age at initial implantation was 59.9 years. Median time from initial implant to pre- sentation with infectious symptoms was 2.4 months, and revision was performed a median of 1.5 days after presentation and initiation of antibiotics. Intraoperative complications were rare (5.3%), and post- salvage complications were 21.1%, including 1 cylinder herniation and 3 post salvage infections (15.8%). Only 1 post-salvage infection showed concordance with initial cultures while 1 was discordant and the third showed no growth (Table 1). Fisher's exact test showed diabetes, purulence in the operative field, use of drain, or washout type were not associated with infection post-salvage. CONCLUSIONS: Immediate IPP salvage in the setting of an acutely infected field shows a complication profile not exceeding pub- lished data in the staged revision setting. Although staged MP-IPP salvage has been favored by many surgeons, the complication profile may be equivalent to immediate IPP salvage, and the risks of a subsequent operation should be considered during preoperative counseling. Source of Funding: NA MP57-17 DEFINING THE INCIDENCE OF POSTOPERATIVE SCROTAL HEMATOMA AFTER THREE-PIECE INFLATABLE PENILE PROSTHESIS SURGERY Avery E. Braun*, Architha Sudhakar, Jacob W. Lucas, Philadelphia, PA; Rutul Patel, Martin S. Gross, Lebanon, NH; Jay Simhan, Philadelphia, PA INTRODUCTION AND OBJECTIVE: Development of scrotal hematoma is a rare but serious complication following inflatable penile prosthesis (IPP) surgery. Multiple techniques to mitigate hematoma formation are implemented by penile implant surgeons, including tem- porary device inflation, Mummy wrap usage, drain placement and appropriate suspension of anticoagulation (AC). We assessed the incidence of scrotal hematoma formation in primary and complex IPP recipients managed with these techniques. METHODS: This is a multicenter retrospective review of 246 patients from 2/2018 to 12/2020 with 194 (78.9%) primary and 52 (21.1%) complex IPP surgeries. Revisions, removal/replacements, or IPPs with concomitant procedures were considered complex. All pa- tients underwent surgery with appropriate suspension of AC as well as postoperative Mummy wrap and drain placement. Drain outputs on postoperative day (POD) 0 and 1 were collected. Device activation varied between two and four weeks, based on surgeon preference. Vol. 206, No. 3S, Supplement, Monday, September 13, 2021 THE JOURNAL OF UROLOGY Ò e985 Copyright © 2021 American Urological Association Education and Research, Inc. Unauthorized reproduction of this article is prohibited.