Contents lists available at ScienceDirect Colloids and Surfaces A journal homepage: www.elsevier.com/locate/colsurfa A systematic surface studies on the glycolipids to understand the surface adsorption behavior Kanaparedu P.C. Sekhar a,b , Prakriti Ranjan Bangal c , Rati Ranjan Nayak a,b, ⁎ a Centre for Lipid Science and Technology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India b Academy of Scientific and Innovative Research (AcSIR), New Delhi, 110 001, India c Analytical Division, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India GRAPHICALABSTRACT ARTICLEINFO Keywords: Glycolipids Surface adsorption Langmuir-Blodgett flms Greater uncertainty in A min 5 M NaCl sub-phase ABSTRACT Modular design of highly functionalized glycolipids from the natural origins provides attractive environmentally benign glycolipids with a wide range of interfacial applications. Linear correlation of single chain glycolipid’s surface properties at hydrophobic chain length ≥ 14 is a challenging task by using surface tension (ST) study. The interfacial area per molecule of the glycolipid is responsible for efcient molecular packing and surface activity at the interfaces. In this regard, ST and Langmuir-Blodgett (LB) techniques were collectively employed on a matrix of nine glycolipids with diferent headgroups at various alkyl chain lengths (C 7 -C 21 ) to elucidate adsorption properties. Surface parameters obtained from ST studies in water as well as in 5 M aqueous NaCl solution has no trend, possible due to deviation from ideal surface behavior. Whereas, water and 5 M NaCl sub- phase LB studies provided a linear structure-property relationship for the glycolipids under investigation. Finally, ST and LB studies collectively reduced the ambiguity in understanding the surface behavior of the glycolipids. 1. Introduction Surfactants derived from natural resources gained much interest in the area of biophysics and physical chemistry. In particular, carbohydrate-based surfactants are key components in a diverse range of products in biomedical research [1]. Specifcally designed carbohy- drate based surfactants were employed to control the surface chemistry at interfaces and fnd applications in personal care products because of https://doi.org/10.1016/j.colsurfa.2018.12.007 Received 23 October 2018; Received in revised form 3 December 2018; Accepted 4 December 2018 ⁎ Corresponding author at: Centre for Lipid Science and Technology, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India. E-mail address: rrnayak@iict.res.in (R.R. Nayak). Colloids and Surfaces A 563 (2019) 226–236 Available online 05 December 2018 0927-7757/ © 2018 Elsevier B.V. All rights reserved. T