Haemophilia. 2019;1–6. wileyonlinelibrary.com/journal/hae | 1 © 2019 John Wiley & Sons Ltd 1 | INTRODUCTION Although many studies of the impact of haemophilia on the health‐ related quality of life (HRQoL) and social status were conducted all over the world, 1 specific data pertaining to Lebanese persons with haemophilia (PWH) are lacking. PWH are at risk of bleeding, especially in the joints, haemophilic arthropathy being the main comorbidity in adult patients who did receive adequate treatment during childhood. 2,3 These complications must be properly managed as they can aggravate the impact of their illness on the physical and psychosocial level and consequently affect their HRQoL. 4,5 The first specific antihaemophilia treatment was introduced in Lebanon in 1996, so the majority of our adult PWH population could not ben‐ efit from adequate treatment. Some studies around the world have Received: 1 December 2018 | Revised: 14 January 2019 | Accepted: 14 January 2019 DOI: 10.1111/hae.13694 ORIGINAL ARTICLE The impact of haemophilia on the social status and the health‐related quality of life in adult Lebanese persons with haemophilia Elie Naous 1,2 | Philippe de Moerloose 3 | Ghassan Sleilaty 1 | Alessandro Casini 3 | Claudia Djambas Khayat 1,2 1 Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon 2 Lebanese Association of Hemophilia, Jal El Dib, Lebanon 3 Division of Angiology and Haemostasis, University Hospitals and Faculty of Medicine, Geneva, Switzerland Correspondence Elie Naous, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon. Email: elie-naous@hotmail.com Introduction: Health‐related quality of life (HRQoL) studies are increasingly needed to prevent and improve the medical care of persons with haemophilia (PWH). Aim: We assessed the impact of haemophilia on HRQoL and social status of adult Lebanese PWH compared to a reference population. Methods: In this case‐control study, 60 severe and moderate PWH were compared to 112 healthy controls. Detailed socio‐demographic data and disease characteristics were collected, and HRQoL was assessed using the SF‐36 questionnaire. Results: Age, body mass index and the percentage of married people were similar in PWH and controls. A greater proportion of controls attained a higher educational level than cases (88.4% vs 59.3%, respectively, P < 0.001). PWH were more likely to have a job requiring physical activity than controls (55.9% vs 31.4%) and more likely to be unemployed (10.2% vs 1.0%), whereas more controls had higher socio‐economic jobs (10.5% vs 1.7%). PWH had significantly (P < 0.001) worse scores in all SF‐36 domains except for energy/fatigue. Affected targeted joints (2.7 ± 1.5) and monthly bleeding frequency (2.9 ± 2.4) were inversely correlated with almost all SF‐36 domains. Only 26.7% of PWH walk normally, and walking abnormalities were inversely correlated with all SF‐36 domains except role‐emotional and emotional well‐being. Conclusion: As compared with controls, the majority of Lebanese PWH has difficulties in social integration, has severe physical limitations and psychological impairments. KEYWORDS education, haemophilia, Lebanon, quality of life, sexuality, SF‐36 questionnaire