15 JURNAL RADIOGRAFER INDONESIA, ISSN 2620-9950 PERUBAHAN VOLUME TUMOR POST-RADIASI EKSTERNA PADA PASIEN KANKER NASOFARING Aidilawarti K. S. 1) , Guntur Winarno 2) , Asumsie Tarigan 2) , Moh. Haris 3) 1) Radiografer RS Eka Hospital Pekabaru Riau 2) Dosen Jurusan Teknik Radiodiagnostik dan Radioterapi, Politeknik Kesehatan Kementerian Kesehatan Jakarta II Kebayoran Baru, Jakarta Selatan 12120 3) Radioterapis Instalasi Radioterapi Rumah Sakit Pusat Kanker Nasional Dharmais, Slipi, Jakarta Barat 11420 Email : aidilawartiks@yahoo.com ABSTRACT Introduction: The radiotherapists provides fractional treatment effectively and efficiently. The expected radiation response can be achieved for tumor volume change so that the principle in radiotherapy is to kill as many cancer cells as possible. However, due to the prognostic factors that may affect the radiation response such as Epstein-Barr Virus, TNM stage system, primary tumor, patient age, sex, type of treatment, and histopathology. Objective: This study is intended to analyze changes in the volume of external post-radiation tumors in nasopharyngeal cancer patients. Methods: This study is a descriptive quantitative study to determine changes in tumor volume from pro- radiation to post-radiation in patients with nasopharyngeal cancer. The sample used was the secondary data which belongs to Radiotherapy Installation at Dharmais Cancer Hospital Jakarta in patients with nasopharyngeal cancer in 2017. The study sample was taken on subjects who meet the criteria of inclusion and exclusion. Results: From the 51 study samples, the results are obtained based on stages, post-radiation tumor volume changes from stage II, III, and IV by 206.56643cc, 135.81397cc, and 168.83302cc. By sex, post- radiation tumor volume changes of male and female sexes were 174,18946cc and 176,02196cc. By age, post-radiation tumor volume changes in the age group 20-39 years, 40-49 years and> 50 years of 183.42215cc, 175.36875cc, and 166.95548cc. Conclusion: It can be concluded that the largest tumor volume change which leads to radiation effectiveness and better prognosis based on stage is at stage II, based on sex is on female gender, and by age was in the age group of 20-39 years. Keywords: Tumor volume change, Post-radiation, Nasopharyngeal cancer Pendahuluan Kanker nasofaring bersifat radiosensitif (Kentjono WA et al, 2003) sehingga radioterapi selalu menjadi pilihan pengobatan utama untuk mematikan semua sel kanker di nasofaring (Nurmasari S et. al, 2007 dan Lo KW et al 2004). Di Indonesia, kanker nasofaring termasuk kanker tertinggi di regio kepala dan leher (Muin A, et a1, 2009 dan Brillian Putri E, et al, 2011) dengan laki-laki 2–3 kali lebih sering terkena dari pada perempuan (Rahman S, et al, 2015). Kanker nasofaring sebagian besar ditemukan pada pasien yang berusia di atas 20 tahun, yaitu antara 50–70 tahun dan paling banyak pada usia produktif yaitu antara 30–59 tahun dengan puncak antara 40–49 tahun, dan tidak ada peningkatan setelah usia 60 tahun (Brillian Putri E, et al, 2011). Untuk stadium awal, tumor hanya menimbulkan gejala yang tidak khas dan tidak spesifik ((Muin A, et a1, 2009 dan Christanti J, 2011) karena terletak di daerah yang sulit dilihat dari luar dan sering tidak dikenali karena keluhan yang sangat umum (Brillian Putri E, et al, 2011) namun dalam stadium ini peran radioterapi sangat baik (Kentjono WA et al, 2003). Akan tetapi, apabila diagnosis terlambat (Ayu D, et al, 2015) dan muncul benjolan pada kelenjar leher ( Kurniawati D, et al, 2013 dan Faiza S, et al,