International Journal of Advances in Medicine | April 2021 | Vol 8 | Issue 4 Page 557 International Journal of Advances in Medicine Nagrani S et al. Int J Adv Med. 2021 Apr;8(4):557-562 http://www.ijmedicine.com pISSN 2349-3925 | eISSN 2349-3933 Original Research Article Study of exercise treadmill test in type 2 diabetes mellitus patients Sahil Nagrani, Prajakta Patil, Supriya S. Barsode*, Nisarg Momale, Parth Mehta INTRODUCTION Thirty million people suffer from diabetes in India according to the study of diabetic society of India. Type 2 diabetes is the most prevalent form of diabetes. There has been a global epidemic of type 2 diabetes mellitus more so in the developing world. 1,2 Myocardial involvement in diabetes may occur relatively earlier impairing early diastolic relaxation. The greatest cause of mortality in type 2 diabetes is coronary artery disease and its sequelae. 3 The Framingham study has shown that cardiovascular mortality is twice in diabetic men and four times in diabetic women as compared to non- diabetic counterparts. Exercise is a common physiological stress used to elicit cardiovascular abnormalities not present at rest and to determine adequacy of cardiac function. It has emerged as the most practical and non- invasive means of discovering latent ischemic heart disease. The diagnostic value of the stress test is maximum when applied to a population in which the diagnosis is most uncertain. Even when there is no history of chest pain, there exists a strong possibility of significant narrowing in the coronary tree in patients with appropriate risk factors, especially diabetes mellitus. An attempt will be made through this study to detect early disease and offer treatment modalities to asymptomatic patients having diabetes mellitus. ABSTRACT Background: The aim of this study was to assess the prevalence and clinical predictors of silent myocardial ischemia in patients with type 2 diabetes mellitus, and the early diagnosis of coronary artery disease. Methods: A cross sectional prospective study was conducted including all confirmed diabetic patients in the age group between 40-60 in Bharati medical college hospital Pune in western Maharashtra. A detailed clinical examination and history was taken and relevant laboratory investigations, Electrocardiogram and Treadmill Stress test was done using Bruce protocol. The quantitative data was represented as their mean ± SD. Categorical and nominal data was expressed in percentage. All analysis was carried out by using SPSS software version 21. Results: Male preponderance was seen in the study with 64% of the study subjects. The mean age of the study subjects was 50.67±5.51 years. A p<0.001 was obtained showing positive correlation between BMI and TMT positivity. TMT positivity steadily increased with the duration of diabetes mellitus. Obtained p<0.001. The correlation between dyslipidemia and TMT positivity was significant, with a p=0.007. Correlation of Fasting as well as Post-prandial blood glucose levels with TMT positivity proved to be statistically significant, with a p<0.001. Conclusions: Exercise Treadmill test in diabetic patients has a significant role in screening diabetic individuals for coronary ischemia. The results obtained clearly indicate that an exercise treadmill test may be proposed as the first test for screening for coronary ischemia in diabetic population as it is safer, cheaper and non-invasive. Keywords: Diabetes Mellitus, Treadmill test, Coronary heart disease, Blood sugar, Bruce protocol Department of Medicine, BVDUMC, Pune, Maharashtra, India Received: 11 February 2021 Accepted: 16 March 2021 *Correspondence: Dr. Supriya S. Barsode, E-mail: supriyabarsode@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: https://dx.doi.org/10.18203/2349-3933.ijam20211055