Abstracts vii130 NEURO-ONCOLOGY • November 00 may result in surgical outcome and survival disparities among different races. Length of stay (LOS) is an important quality metric measure for determining the distribution of medical resources and their consumption. This study aims to provide a perspective on racial disparities in the overall length of stay and complications for patients undergoing craniotomy for primary brain glioma. METHODS: The authors performed a retrospective chart review of all patients who underwent craniotomies for resection of pri- mary brain tumors at the Mofftt Cancer Center from 2004-2018. Patients age, race, tumor type, comorbidities, length of stay and complications were reviewed. RESULTS: A total of 701 patients underwent craniotomies for primary brain glioma, but 66 were excluded due to insuffcient follow-up or incomplete records. The racial categories include Caucasians, African American, Asian, Hispanic, and other.  Due to the prevalence of Caucasians, the minorities groups were pooled as non-Caucasians. Both cohorts were similar in baseline comorbidities, KPS, tumor characteristics, and surgical factors. Mean LOS remained lower for Caucasians versus non-Caucasians (3.6 vs. 5.5 d). The differences in LOS remain among different tumor types, including GBM (4 vs. 6.7 d), anaplastic astrocytoma (2 vs. 4.4 d), and oligo- dendroglioma (2.3 vs. 3.7 d). Interestingly, among astrocytoma, Caucasians had a longer LOS (3 vs 1.2 d). CONCLUSION: Our results highlight dis- parate treatment patterns that refect in LOS among patients undergoing craniotomies for primary brain gliomas. These fndings warrant further in- vestigation regarding current health-care practices and policies. DISP-13. FEMALE MICE HAVE GREATER SUSTAINED ACTIVITY SUPPRESSION AND HYPERSOMNOLENCE AFTER RADIATION THERAPY: EXPLORATION OF SEX DIFFERENCES IN A MODEL OF CRANIAL-RADIATION-INDUCED HYPERSOMNOLENCE (C-RIH) Kendra Adegbesan 1 , Francesco Tomassoni Ardori 2 , Sudhirkumar Yanpallewar 2 , Sean Bradley 3 , Yogita Chudasama 4 , Nicole Briceno 5 , Amanda King 1 , Lino Tessarollo 2 , Mark Gilbert 1 , DeeDee Smart 2 , Terri Armstrong 1 , and Dorela Shuboni-Mulligan 1 ; 1 Neuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA, 2 Neuro Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, USA, 3 Rodent Behavior Core, National Institute of Mental Health, National Institutes of Health, Bethesda, USA, 4 Section on Behavioral Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, USA, 5 National Institutes of Health, National Cancer Institute (NCI), Center for Cancer Research (CCR), Neuro-Oncology Branch (NOB), Bethesda, MD, USA Female cancer patients have a better prognosis but more adverse events with chemotherapy; less is known with other cancer treatments like radi- ation therapy. Previous literature has demonstrated sex-dependent effects on the hippocampi and behavioral tasks within post-natal mice after radio- therapy. We explored the differences in activity and sleep in adult male and female mice within our previously established mouse model of cranial- irradiation-induced hypersomnolence (C-RIH). Ten mice of each sex (B6 x B6D2 backcrossed with C57/b6NCr) were observed for general activity and sleep continuously over 10 days before and after therapeutic irradi- ation (whole brain, 15Gy, single fraction). Behavioral assessments aimed at measuring anxiety (Light Dark Box, Elevated Zero Maze) and depression (Sucrose Preference Test) related behaviors, and working memory (Y Maze) were then used to assess any radiation-induced changes in mood or cogni- tion. Independent samples t-tests compared male and female cohorts before and after radiation. At baseline, females had signifcantly higher peak ac- tivity (p < 0.001), as well as day (p < 0.001), and night (p = 0.004) activity. Females also showed less anxiety in the Elevated Zero Maze (p < 0.001) and Light-Dark Box (p = 0.012). In the Y-Maze, females had signifcantly more alternations (entry into each arm without repeat) (p = 0.004). Males and females consumed the same proportion of sucrose solution in respect to water (p = 0.124). After radiation, males and females showed a signifcant decrease in activity, with females displaying a higher suppression of night activity both 1-3 days (t(18) = 2.162, p = 0.045) and 7-9 days (t(18) = 2.266, p = 0.037). Female mice also showed increased night hypersomnolence at 1-3 days (t(18) = 4.474, < p = 0.001) and 7-9 days (t(18) = 2.920, p = 0.01). Further analysis is underway on post-radiation sex differences in sleep and activity. Here we used a mouse model of C-RIH to assess the behavioral outcomes between the sexes and found marked effects on sleep and activity. DISP-14. DEFINING INTERVENTIONS AND METRICS TO IMPROVE DIVERSITY IN CNS CLINICAL TRIAL PARTICIPATION: A SNO AND RANO EFFORT   Joshua Budhu 1 , Alyx Porter 2 , Sadhana Jackson 3 , Eudocia Lee 4 , J. Ricardo McFaline-Figueroa 4 , Nicole Willmarth 5 , Mahalia Dalmage 6 , Ichiro Kawachi 7 , David Arons 8 , Susan M. Chang 9 , Patrick Y. Wen 10 , Shawn L. Hervey-Jumper 11 , and Ugonma Chukwueke 4 ; 1 Memorial Sloan Kettering Cancer Center, Boston, MA, USA, 2 Mayo Clinic Arizona, Scottsdale, AZ, USA, 3 National Institutes of Health, BETHESDA, MD, USA, 4 Dana-Farber Cancer Institute, Boston, USA, 5 American Brain Tumor Association, Park Ridge, USA, 6 National Institutes of Health, Bethesda, USA, 7 Harvard T.H. Chan School of Public Health, Boston, USA, 8 National Brain Tumor Society, Boston, USA, 9 University of California, San Francisco, San Francisco, CA, USA, 10 Dana-Farber Cancer Institute, Boston, MA, USA, 11 University of California, San Francisco, San Francisco, USA Despite major strides in cancer research, care, and therapy, these advances have not been equitable across race and ethnicity. Groups underrepresented in medicine (URM) are more likely to have inadequate preventive screening, increased delays in diagnosis, and poor representation in clinical trials. Not- ably, Black and Latino Americans represent 29% of the population but only refect 8% of oncology clinical trial participants. Recent studies have shown that this disparity is also present in neuro-oncology as women, Black, and La- tino Americans remain under-accrued in clinical trials. Brain tumor patients already face unique barriers to clinical trial enrollment and completion due to disease-specifc conditions–such as impaired motor function, cognition, lan- guage defcits, and caregiver dependency–which pose additional diffculties in clinical trial consent, enrollment, and adherence. As part of this collaborative initiative, we evaluated the impact of how a lack of diversity in cancer re- search is detrimental to scientifc discovery and propose interventions focused on improving URM engagement with clinical research. Recommendations in- clude the creation of inclusive trial design at the onset, decreasing barriers to care, expanding trial eligibility, and equitable access to tumor profling for personalized medical trials. Additionally, setting reasonable metrics and goals for accrual and engagement with patient and community stakeholders will ultimately help to diversify trial participants. Lastly, diversifcation and inclu- sion practices within the neuro-oncology workforce, including all personnel involved in clinical research, will help to minimize bias, promote concordant care, and assist with developing sustainable solutions. The diversifcation of participation in neuro-oncology clinical trials is imperative. The lack of diver- sity in clinical trials can contribute to improper generalizability of treatment effcacy, resulting in potentially harmful practices. Equitable access and inclu- sion of URM brain tumor patients will not only enhance research discoveries but will also result in improved patient care for all cancer patients. DISP-15. TRENDS IN LASER INTERSTITIAL THERMAL THERAPY (LITT): HOW RACE AND SOCIOECONOMIC FACTORS IMPACT ACCESS  Danielle Terrell 1 , Sandeep kandregula 1 , Joshua Caskey 1 , and christopher Newman 2 ; 1 LSU Shreveport, Shreveport, LA, USA, 2 Memorial Sloan Kettering Hospital, New York, NY, USA Introduction This study seeks to examine the trends of laser interstitial thermal therapy (LITT) access in the pre-and post-Medicaid expansion time periods; and more specifcally, how racial and socioeconomic factors impact access.  Methods The National Inpatient Sample (NIS) database was queried for all patients who received LITT from 2010 to 2019 for any indication. Age, gender, race, payer status, and median income by zip code were obtained and compared for the pre-Medicaid expansion (2010-2014), and post-Medicaid expansion (2015-2019) groups. Chi-square analysis was performed for cat- egorical variables, and the student t-test was used to analyze continuous variables. Results The pre-Medicaid expansion (n = 915) and post-Medicaid (n = 3205) time periods were similar in that Whites were the overwhelming majority of LITT recipients (78.7% and 70.8%, p < 0.001). In 2010, all races had low rates of LITT, as would be expected with a new emerging treatment. Although the absolute value of the percentages seems similar, between 2013 and 2014, the proportion of Whites receiving LITT nearly doubled (from 45% to 75%); while all other groups had no signifcant increase in utilization. Util- ization of LITT by Black Americans remained stable, 5.4% and 5.6% in the pre- and post-Medicaid expansion eras, while Hispanics and Others saw slight increases in utilization (8.8% to 10.1% and 7.1% to 13.4% respectively). Although Medicare and Medicaid usage increased over the years, private in- surance remained the primary payer for LITT (53.8% and 49.3%, p 0.018). Lastly, patients within the highest income quartiles comprised over half of LITT procedures done in the study period (56.8% and 52.8%, p 0.029).   Conclusion Despite nearly a decade and the effects of Medicaid expansion via the Affordable Care Act, LITT is still diffcult to access for patients of color, Medicare and Medicaid users, and patients in low-income locales.   DISP-16. NUTRITIONAL SCREENING OF PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR SURVIVORS REVEALS HIGH PREVALENCE OF MALNOURISHMENT WITH SOCIODEMOGRAPHIC AND CLINICAL RISK FACTORS   Rebekah Wilson 1 , Jacqueline Soja 1 , Alexandra Yunker 1 , Rahela Aziz-Bose 1 , Erin Gordon 2 , Christina Dieli-Conwright 1 , and Tab Cooney 3 ; 1 dana farber cancer institute, boston, USA, 2 boston children's hospital, boston, USA, 3 dana farber cancer institute, Boston, MA, USA Adult survivors of pediatric central nervous system (CNS) tumors are at the highest risk for morbidity and late mortality among all childhood cancers, partially due to chronic health conditions intersected with environmental and lifestyle factors. We aimed to study the prevalence of and risk factors for mal- nourishment (underweight, overweight, obese) amongst adult survivors of pedi- atric CNS tumors. We conducted a cross-sectional study assessing young adults Downloaded from https://academic.oup.com/neuro-oncology/article/24/Supplement_7/vii130/6826027 by guest on 17 November 2022