ORIGINAL RESEARCH Journal of Dentomaxillofacial Science (J Dentomaxillofac Sci ) December 2020, Volume 5, Number 3: 158-161 P-ISSN.2503-0817, E-ISSN.2503-0825 158 © 2020 JDMFS. Published by Faculty of Dentistry, Hasanuddin University. All rights reserved. http://jdmfs.org CrossMark Ab stract Objective: To compare the osteoblast cell formation process after installation implant with and without added of platelet-rich plasma (PRP). Methods: Twenty-four male rabbit were selected by purposive sampling, divide into two groups. Group 1 implant with added PRP were installation in the distal part of the thigh bone 12 male rabbits, Group 2 implants without the addition of PRP mounted on the distal part of the thigh bone 12 male rabbits. All rabbits in euthanasia after 0, 7, 14, and 28 days were then analyzed histologically to determine the formation of osteoblast cells. Results: There is increased formation of osteoblast cell formation in implant installation with the addition of PRP when compared with implants without PRP as time increases. Conclusion: Administration of PRP in implants can speed up and increase osteoblast cell formation. Keywords: Bone remodeling, Implant, Platelet- rich plasma Cite this Article: Machmud E, Thalib B, Dharmautama M, Mude AH, Dammar I, Ikbal M. 2020. Platelet-rich plasma improves initial bone remodeling. Journal of Dentomaxillofacial Science 5(3): 158-161. DOI: 10.15562/jdmfs.v5i3.688 Platelet-rich plasma improves initial bone remodeling Edy Machmud, * Bahruddin Thalib, Mochammad Dharmautama, Acing H. Mude, Irfan Dammar, Muhammad Ikbal Introduction Correction of bone defects in the installation of dental implants can be accelerated by adding platelet-rich plasma (PRP) material that can initi- ate wound healing by releasing locally employed growth factors. 1-3 Platelet-rich plasma is a protein taken autologous, using regeneration of the body itself, so it has the advantage that; PRP can prevent disease transfer and immunologic reactions, PRP is easy to obtain because it comes from self-administered animal blood, time is short, easy and safe to apply, PRP has high fbrin content, PRP accelerates epithelial, endothelial and epidermal regeneration which can promote tissue healing through angiogenesis and collagen synthesis, PRP can accelerate bone formation and maturation. 4 Bone formation begins with the release of platelet derive growth factor (PDGF), TGF and IGF. Vascular endothelial growth factor increases endothelial growth proliferation. Platelet derived growth factor will bind to endothelial cells to initi- ate wound healing through collagenase activity. Transforming growth factor-beta (TGF-B) will bind to osteoblasts and stem cells to stimulate oste- oid production resulting in bone resorption and woven bone formation. 5 PRP is a platelet in gel form extracted through centrifugation of bovine thrombin mixture, 10% calcium chloride and venous blood. PRP also contains signifcant growth factor concen- trations that will increase bone formation and mineralization, induce stem cells to diferentiate into osteoblasts, minimize bone resorption, increase angiogenesis and produce collagen through fbroblast activation. 6,7 Te purpose of this study was to analyze the efect of the addition of PRP on the installation of dental implants to the initial bone remodeling. Tis research is almost similar to the research done by Brunamelia de Oliviera on the evaluation of biomaterials with and without platelet-rich plasma: a histometric study using beagle dogs, but diferent in terms of methods, and research samples. In this study only use the time from the frst day to the fourteenth day because only want to see the initial bone formation. Material and Methods Twenty four New Zealand rabbits, aged 4-8 months, weight 1500-2000 grams maintained for seven days in clean, air-free cage, fed and drank three times a day. Divided into two groups, the frst group contained twelve rabbits placed implanted with PRP on her thighbone, the second group containing 12 rabbits placed an implant without PRP on her thighbone. Furthermore each 3 rabbits will be sacrifced afer 1, 3, 7, and 14 days afer implant installation both in frst and second group. Intake of bone tissue around the implantation area, making histologic preparations to calculate the number of osteoblast cells using an Optilab microscope Raster V3 image with magnifcation 10, 40 and 100. Department of Prosthodontics, Faculty of Dentistry Hasanuddin University, Makassar, Indonesia * Correspondence to: Edy Machmud, Department of Prosthodontics, Faculty of Dentistry Hasanuddin University, Makassar, Indonesia machmudedy@gmail.com Received: 11 April 2018 Revised: 20 August 2019 Accepted: 15 December 2019 Available Online: 1 December 2020