Journal of Experimental Biology and Agricultural Sciences http://www.jebas.org ISSN No. 2320 – 8694 Journal of Experimental Biology and Agricultural Sciences, October - 2022; Volume – 10(5) page 978 – 986 Impact of Metallic Nanoparticles on the Nutritional Values of Spirulina Raveenderan Sithambaram 1 , Sinouvassane Djearamane 2* , Sharolynne Xiao Tong Liang 2 , Ling Shing Wong 3 , Ranjithkumar Rajamani 4 , Senthilkumar Balasubramanian 5 1 Department of Food and Agriculture Science, Faculty of Science, UniversitiTunku Abdul Rahman, Kampar, Perak, Malaysia 2 Department of Biomedical Science, Faculty of Science, UniversitiTunku Abdul Rahman, Kampar, Perak, Malaysia 3 Department of Biotechnology, Faculty of Health and Life Sciences, INTI International University, Nilai, Negeri Sembilan, Malaysia 4 Viyen Biotech LLP, Coimbatore, Tamil Nadu – 641 031, India 5 Department of Zoology, Thiruvalluvar University, Vellore, Tamilnadu, India Received – January 26, 2022; Revision – March 16, 2022; Accepted – March 29, 2022 Available Online – October 31, 2022 DOI: http://dx.doi.org/10.18006/2022.10(5).978.986 ABSTRACT Spirulina has high nutritional values and anti-oxidative properties. It is a staple diet due to its easy cultivation and greater nutritional values in biological macromolecules (proteins, lipids, and carbohydrates), pigments (chlorophyll, carotenoids, phycobiliproteins) vitamins, minerals, phenolic compounds, and amino acids. Spirulina also has been used as a nutraceutical to treat numerous diseases and disorders due to its promising therapeutic values. However, extensive anthropogenic activities cause the discharge of metals and metallic nanoparticles into the environment that might cause toxicity to marine and freshwater microalgae due to bioaccumulation. The presence of metals in the environment beyond the normal range does not only affect the growth but also the nutritional values of microalgae. The nutritional properties and usage of Spirulina along with the harmful effects of metals and metallic nanoparticles on Spirulina are highlighted and summarized in this paper. * Corresponding author KEYWORDS Spirulina Nutritional properties Cyanobacteria Metal toxicity Environmental toxicity Therapeutic values E-mail: sinouvassane@utar.edu.my (Sinouvassane Djearamane) Peer review under responsibility of Journal of Experimental Biology and Agricultural Sciences. All the articles published by Journal of Experimental Biology and Agricultural Sciences are licensed under a Creative Commons Attribution-NonCommercial 4.0 International License Based on a work at www.jebas.org. Production and Hosting by Horizon Publisher India [HPI] (http://www.horizonpublisherindia.in/). All rights reserved.