ELSEVIER PI-C+ Neum-Psychopharmacol. &Bid. zyxwvutsrqponmlkjihgfedcba Psychiat. 1997, Vol. 21. pp. 487-505 copyright 8 1997 Elswier Science Inc. printed in the USA. All rights reserved 0278.5846197 S32.M) + .oO zyxwvut PII SO276-5S46(97)66614-6 zyxwvutsrqponmlkjihgfedcbaZYXWVUT THE CONTRIBUTION OF PROTEIN KINASES TO PLASTIC EVENTS IN THE SUPERIOR COLLICULUS DAMIAN McCROSSAN, DEBORAH J. WITHINGTON and BETTINA PLATT Department of Physiology, Worsley Medical and Dental Building, University of Leeds, Leeds, UK (Final form, January 1997) Contents 1. 1.1. 1.2. 2. 2.1. 2.1.1. 2.1.2. 2.1.3. 3. 3.1. 3.1.1. 3.1.2. 4. 4.1. 4.1.1. 4.1.2. 4.1.3. 4.2. 4.2.1. 4.2.2. 4.2.3. 5. Abstract Introduction The Superior Colliculus or Optic Tectum Activity Driven Plastic Events The Frog The Formation of Dually Innervated Tecta Effects of NMDA Receptor Antagonists Effects of Protein Kinase Inhibitors Quantification of Observations The Goldfish Regeneration of the Optic Nerve Activity Dependence of Visual Map Reformation The Effect of Protein Kinase Manipulations The Guinea-Pig The Guinea-Pig SC in Vitro SC-LTP The Effects of NMDA Receptor Antagonists The Effects of Protein Kinase Inhibitors The Guinea-Pig SC in Vivo Experience-Dependent Map Formation The Effects of Chronic Exposure to a NMDA receptor Antagonist The Effects of Chronic Exposure to a Protein Kinase Inhibitor Conclusions Acknowledgements References