Journal of Advanced Medical Research Vol.4 No.1, March 2014, 10-20 10 Biochemical and hematological parameters in relation to Helicobacter pylori infection among type 2 diabetic patients in Gaza Strip Maged M. Yassin 1, a , Abdel Monem H. Lubbad 2, b , Nabil M. Saadallah 3, c , Ahmed J. AbuTaha 4, d 1Department of Physiology, Faculty of Medicine, The Islamic University of Gaza, Palestine. 2Department of Pathology, Faculty of Medicine, The Islamic University of Gaza, Palestine. 3Department of Microbiology, Faculty of Science, The Islamic University of Gaza, Palestine. 4Department of Biology and Biotechnology, Faculty of Science, The Islamic University of Gaza, Palestine. myassin@iugaza.edu.ps ISSN: 2231-9123 ABSTRACT The present study is aimed to assess biochemical and hematological parameters in relation to Helicobacter pylori (H. pylori) infection among type 2 diabetic patients in Gaza Strip. This case- control study comprised 90 type 2 diabetic patients (45 males and 45 females) and 90 healthy controls (45 males and 45 females). Blood samples were collected, processed and analyzed. Serum H. pylori IgG was determined by enzyme-linked immunosorbent assay (ELISA). Biochemical tests and complete blood count were performed. Data were analyzed using SPSS version 18.0. Blood glycated hemoglobin (HbA1c), serum insulin, cholesterol, triglycerides, aspartate aminotransferase (AST), alanine aminotransferase (ALT) as well as white blood cell (WBC) and platelet (PLT) were found to be significantly higher in diabetic patients compared to controls (P<0.05). The prevalence of H. pylori among diabetic patients 65 (72.2%) was significantly higher than controls 33 (36.7%) with P=0.000. When related to H. pylori, HbA1c was significantly higher in positive than in negative cases (8.4±1.8 vs 7.6±1.5 %, P=0.042). Cholesterol and triglycerides were significantly increased in H. pylori positive cases (216.4±42.5 and 190.1±91.9 mg/dl, vs 195.6±42.6 and 164.5±61.2 mg/dl, P=0.041 and P=0.033, respectivily). The activity of ALT was also increased in H. pylori positive cases (43.1±4.9 vs 40.8±4.8 U/L P=0.049). The WBC was singnificantly elvated in H. pylori positive cases (8.1±1.8 vs 7.2±1.5 ×10 9 /L, P=0.038). In conclusions, H. pylori infection was significantly higher in type 2 diabetic patients compared to controls. H. pylori infection was associated with HbA1c, cholesterol, triglycerides, ALT and WBC. Keywords: Helicobacter pylori, biochemical and hematological parameters, Type 2 diabetes, Gaza Strip. 1. Introduction Diabetes mellitus is a metabolic disorder characterized by the presence of chronic hyperglycemia accompanied by greater or lesser impairment in the metabolism of carbohydrates, lipids and proteins. The origin and etiology of diabetes mellitus can vary