Research Article Lymphocyte Oxidative Stress/Genotoxic Effects Are Related to Serum IgG and IgA Levels in Coke Oven Workers Meili Gao, 1 Yongfei Li, 2 Aqun Zheng, 3 Xiaochang Xue, 4 Lan Chen, 5 and Yu Kong 1 1 Department of Biological Science and Engineering, Institute of Mitochondrial Biology and Medicine, Te Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xianning West Road 28, Xi’an, Shaanxi 710049, China 2 School of Materials and Chemical Engineering, Xi’an Technological University, Xi’an 710032, China 3 School of Science, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China 4 Department of Biopharmaceutics School of Pharmacy, State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an, Shaanxi 710032, China 5 Center of Shared Experimental Facilities, Te Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China Correspondence should be addressed to Yu Kong; kynk@sina.com Received 17 January 2014; Revised 7 June 2014; Accepted 9 June 2014; Published 20 July 2014 Academic Editor: Raimo Pohjanvirta Copyright © 2014 Meili Gao et al. Tis is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. We investigated oxidative stress/genotoxic efects levels, immunoglobulin levels, polycyclic aromatic hydrocarbons (PAHs) levels exposed in 126 coke oven workers and in 78 control subjects, and evaluated the association between oxidative stress/genotoxic efects levels and immunoglobulin levels. Signifcant diferences were observed in biomarkers, including 1-hydroxypyrene levels, employment time, percentages of alcohol drinkers, MDA, 8-OHdG levels, CTL levels and CTM, MN, CA frequency, and IgG, IgA levels between the control and exposed groups. Slightly higher 1-OHP levels in smoking users were observed. For the dose-response relationship of IgG, IgA, IgM, and IgE by 1-OHP, each one percentage increase in urinary 1-OHP generates a 0.109%, 0.472%, 0.051%, and 0.067% decrease in control group and generates a 0.312%, 0.538%, 0.062%, and 0.071% decrease in exposed group, respectively. Except for age, alcohol and smoking status, IgM, and IgE, a signifcant correlation in urinary 1-OHP and other biomarkers in the total population was observed. Additionally, a signifcant negative correlation in genotoxic/oxidative damage biomarkers of MDA, 8-OH-dG, CTL levels, and immunoglobins of IgG and IgA levels, especially in coke oven workers, was found. Tese data suggest that oxidative stress/DNA damage induced by PAHs may play a role in toxic responses for PAHs in immunological functions. 1. Introduction Coke oven workers are constantly exposed to coke oven emissions which are toxic chemicals, especially polycyclic aromatic hydrocarbons (PAHs). PAHs are formed during combustion of fossil fuels and typifed by the 1-hydroxypyrene levels. Te 1-hydroxypyrene level has been shown to be a good marker for total PAHs exposure [1, 2]. Some of PAHs are carcinogenic due to their metabolites and their ability to generate genetic damage and further oxidative DNA damage through the production of reactive oxygen species during metabolism [3, 4]. Of many indicators for oxidative DNA damage, 8- hydroxy-2  -deoxyguanosine (8-OHdG) represents an important product from oxidative damage to DNA. 8-OHdG is formed in a promutagenic DNA lesion induced by the reaction of hydroxyl radicals with guanosine at the C8 site in DNA. A growing number of surveys and occupational studies indicated that elevated levels of 8- OHdG in DNA from leukocytes or excretion in urine have been observed in PAHs exposure of smokers and workers [5–8]. Malondialdehyde (MDA), which is an end product of the oxidation of polyunsaturated fatty acids and can determine the degree of lipid peroxidation, has been used as a marker for oxidative stress [9]. It has been reported that low level PAH exposure causes DNA single strand breakage, the formation of DNA damages, Hindawi Publishing Corporation e Scientific World Journal Volume 2014, Article ID 801346, 10 pages http://dx.doi.org/10.1155/2014/801346