Journal Pre-proof Increased surface area of halloysite nanotubes due to surface modification predicts lung inflammation and acute phase response after pulmonary exposure in mice Kenneth Klingenberg Barfod, Katja Maria Bendtsen, Trine Berthing, Antti Joonas Koivisto, Sarah Søs Poulsen, Ester Segal, Eveline Verleysen, Jan Mast, Andreas Holl¨ ander, Keld Alstrup Jensen, Karin Sørig Hougaard, Ulla Vogel PII: S1382-6689(19)30140-1 DOI: https://doi.org/10.1016/j.etap.2019.103266 Reference: ENVTOX 103266 To appear in: Environmental Toxicology and Pharmacology Received Date: 25 July 2019 Revised Date: 14 September 2019 Accepted Date: 17 September 2019 Please cite this article as: Barfod KK, Bendtsen KM, Berthing T, Koivisto AJ, Poulsen SS, Segal E, Verleysen E, Mast J, Holl¨ ander A, Jensen KA, Hougaard KS, Vogel U, Increased surface area of halloysite nanotubes due to surface modification predicts lung inflammation and acute phase response after pulmonary exposure in mice, Environmental Toxicology and Pharmacology (2019), doi: https://doi.org/10.1016/j.etap.2019.103266