Open Journal of Obstetrics and Gynecology, 2020, 10, 1573-1579 https://www.scirp.org/journal/ojog ISSN Online: 2160-8806 ISSN Print: 2160-8792 DOI: 10.4236/ojog.2020.10110141 Nov. 16, 2020 1573 Open Journal of Obstetrics and Gynecology Advanced Undifferentiated Endometrial Carcinoma with No Evidence of Disease after Neoadjuvant Chemotherapy: A Case Report Cassandra L. Presti 1 , Payam Katebi Kashi 1 , Christopher M. Tarney 2 , Ruchi Garg 1,3 1 Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Inova Fairfax Women’s Hospital, Falls Church, VA, USA 2 Walter Reed National Military Medical Center, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Bethesda, MD, USA 3 Mid Atlantic Gynecologic Oncology and Pelvic Surgery Associates, Fairfax, Virginia, USA Abstract Background: Neoadjuvant chemotherapy is used in gynecologic malignan- cies as primary treatment for advanced disease and has demonstrated im- provement in survival rates. However, the data for use in endometrial cancer is limited. Case: This is a case of stage IV endometrial undifferentiated carci- noma with complete response to four cycles of neoadjuvant chemotherapy (carboplatin/paclitaxel) and no evidence of disease during the interval de- bulking surgery (robotic-assisted total laparoscopic hysterectomy with bila- teral salpingoophorectomy, pelvic and paraaortic lymph node dissection, and cystoscopy). Conclusion: Complete response to neoadjuvant chemotherapy prior to interval debulking surgery is only reported in a limited number of cases, and even less common in advanced stage high-grade endometrial can- cers. The use of neoadjuvant chemotherapy may reduce tumor burden, in- crease opportunities for optimal debulking, and have an impact on survival. Further research is needed to understand the potential for neoadjuvant che- motherapy in these patients. Keywords Neoadjuvant Chemotherapy, Undifferentiated Endometrial Carcinoma 1. Introduction Endometrial cancer is the most common gynecologic cancer in the United How to cite this paper: Presti, C.L., Kashi, P.K., Tarney, C.M. and Garg, R. (2020) Advanced Undifferentiated Endometrial Carcinoma with No Evidence of Disease after Neoadjuvant Chemotherapy: A Case Report. Open Journal of Obstetrics and Gynecology, 10, 1573-1579. https://doi.org/10.4236/ojog.2020.10110141 Received: September 25, 2020 Accepted: November 13, 2020 Published: November 16, 2020 Copyright © 2020 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access