1 College of Health science, Department of Midwifery, Assosa University, Ethiopia 2 College of Medicine and health science, School of Nursing and Midwifery, Wollega University, Ethiopia 3 College of Medicine and Health science, Department of Midwifery, Wolkite University, Ethiopia Hunduma Dina Hambisa 1* , Diriba Bayisa 2 , Desalegn Emana 1 , Mabratu Demissie 3 * Corresponding author: Hunduma Dina Hambisa*, College of Health science, Department of Midwifery, Assosa University, Ethiopia. Assessment of factors associated with Practice and knowledge of Essential newborn care among nurse and midwives in Assosa zone governmental health facilities, western Ethiopia. Submitted: 16 Nov 2022 Accepted: 22 Nov 2022 Published: 23 Nov 2022 Citation: Hunduma Dina, Diriba Bayisa, Desalegn Emana, Mabratu Demissie (2022). Assessment of factors associated with Practice and knowledge of Essential newborn care among nurse and midwives in Assosa zone governmental health facilities, western Ethiopia. J Clin Nur Rep 1 (1), 01-09. Journal of Clinical Nursing & Reports Research Article Keywords: Essential Newborn care, knowledge, Practice, Nurse and Midwives, Ethiopia J Clin Nur Rep 2022 www.mkscienceset.com Page No: 01 Abstract Introduction: Promoting basic newborn care skills and practices is a cost-efective approach to improving newborn health outcomes. Therefore, this study aimed to assess the essence of the essential knowledge about newborn care, practices and related factors among nurse and midwives in western Ethiopia. Objective: This study intended to assess factors associated with Practice and knowledge of Essential newborn care. Methods: Institutional based cross-sectional study design was conducted. A Convenient sampling technique was applied. Data was collected by interviewer administered structured questionnaires. Data processing and analysis: The collected data was entered into Epi data 3.1version and analyzed by using SPSS version 26. The strength of association between independent and dependent variables was measured by odd ratios with 95% CI at p-value of < 0.05. Result: 98% nurses and midwives w. Mean value of good knowledge and good practice of essential newborn care were 61.7% [95% CI (56.4, 69.8)] and 41.5% [95% CI (38.3, 48.5)] respectively. Being trained, educational qualifcation, availability of newborn care materials and work experience were signifcantly associated with knowledge practice of essential newborn care. Conclusion: This study identifed that knowledge of essential newborn care was average among Nurse and Midwifes; however, the practice of essential newborn care was very low compared to other studies in Ethiopia. Therefore factors identifed; in service training, improving educational qualifcation and increasing accessibility of new born care materials at all facility level are interventional areas to bring required knowledge and practice of Essential new born care. Introduction The transition from intrauterine to extra uterine life is dramatic and requires signifcant and efective physiological changes by the baby to ensure survival [1]. Not only the time of birth, but also the frst hour after birth has a major impact on the surviv- al, future health and well-being of a newborn. Health workers play an important role at the time of birth, and care during this time is critical to avoid complications and ensure survival [2]. Only qualifed care during labor and delivery with immediate complication management can prevent around 50% of newborn mortality and 45% of intra-partum stillbirths [3]. The Essential Newborn Care Protocol is a set of time-bound, chronologically ordered standard procedures that a baby re- ceives at birth to improve the health of newborns through in- terventions before conception, during pregnancy, during and shortly after birth, and in the postnatal period improve [4]. There are four heart of the protocol of ENC ;which are time bound interventions: immediate drying, skin-to-skin contact, followed by disconnecting the umbilical cord after 1 to 3 minutes, not sep- arating the baby from the mother, and starting breastfeeding [5]. Essential newborn care has standardized and efective procedur- al steps: drying and stimulating, assessing breathing, umbilical