UMYU Scientifica, Vol. 1 NO. 1, September 2022, Pp 60 – 66 https://scientifica.umyu.edu.ng/ Murtala et al. /USci, 1(1): 60 – 66, September 2022 ORIGINAL RESEARCH ARTICLE Systematic Review on the Antibacterial Resistance of Vibrio Cholerae Rabiu Murtala 1&2* , Abdulkadir Bashir 3 Isa Abubakar Aliyu 4 , Kumurya Abdulhadi Sale 4 1 Department of Medical Laboratory Services, Ahmad Sani Yariman Bakura Specialist Hospital Gusau, Zamfara State, Nigeria 2 Department of Public Health Ministry of Health Gusau, Zamfara State, Nigeria 3 Department of Microbiology Umaru Musa Yaradua University Katsina State, Nigeria 4 Department of Medical Laboratory Science, Faculty of Health Allied Sciences, Bayero University Kano, Kano State, Nigeria INTRODUCTION Vibrio cholerae causes acute rice watery stool disease that affect human being which form biofilm on the surface water (Gupta et al., 2018).Antibacterial resistance is the ability of bacteria to defeat the drugs designed to kill them and this is one of the greatest global public health difficulties of our period responsible for deaths, prolong hospitalization, and high expenses health-care for specific pathogen–drug treatment. Antimicrobial susceptibility pattern of humans and environmental isolates of V. cholerae is vital in monitoring antibiotic resistance within nations (Gupta et al., 2018). Rise in Antibacterial resistance of V. cholerae has been recorded in numerous epidemics globally (Dengo-Baloi et al., 2017). Integrons continue to be responsible in Vibrio cholerae Antimicrobial resistance (AMR) with capability to recognize AMR gene cassettes and direct them in their hosts (Sulca et al., 2018). Genomic variation and antibacterial resistant V. cholerae have implications in the disease management (Campos et al., 2004). Vibrio cholerae turn Antibacterial resistant by moving the agent through efflux pumps, chromosomal accident or developing genetic resistance via the exchange of conjugative plasmids, conjugative transposons, integrons or self-transmissible chromosomally by integrating SXT (Sulphamethozaxole Trimethoprim) elements (Kitaoka et al., 2011). MATERIALS AND METHODS A systematized PubMed investigation was done by means of the key terms MeSH “Antimicrobial resistance of Vibrio cholerae” between January 2000 and October 2018. Given the extent of the issue, citations were selected for articles published in English. We found 249 papers (Figure 1), but only 77 were chosen and reviewed based on key terms 3 were duplications, 172 were antimicrobial resistance based on other organism and were removed from the review. Correspondence: Kumurya, A. S. Department of Medical Laboratory Science, Faculty of Health Allied Sciences, Bayero University Kano, Kano State, Nigeria. askumurya.med@buk.edu.ng. How to cite: Rabiu, M . ; Abdulkadir, B.; Aliyu, I. A .; Kumurya, A. S. (2022). Systematic Review on the Antibacterial Resistance of Vibrio Cholerae. UMYU Scientifica, 1(1), 60 – 66. https://doi.org/10.47430/usci.1122.009 ISSN: 2955 – 1145 (print); 2955 – 1153 (online) https://doi.org/10.56919/usci.1122.009 A periodical of the Faculty of Natural and Applied Sciences, UMYU, Katsina ABSTRACT Background: Vibrio cholerae is the causative agent of cholera illness. Antibacterial resistance of V. cholerae is frequently experienced due to the environmental pressure from human and animal overuse and misuse of antibacterials. Among such antibacterials include Tetracycline, Chloramphenicol, Furazolidone, Ampicillin, and Trimethoprim-Cotrimoxazole as used against V. cholerae O1, O139 and non O1, O139 strains. Objectives: This systematic review was aimed at providing an overview of Antibacterial resistant strains of Vibrio cholerae in terms of year, location and factors responsible for the resistance. Material and Method: Systematic Electronic database search of PubMed (NCBI) by means of the key terms MeSH “Antimicrobial resistance of Vibrio cholerae” between the period of January 2000 to October 2018 was used. Results: From the findings it showed that many factors are responsible for Antibacterial resistance of Vibrio cholerae which include genetic composition, mutation, enzymes. Also V. cholerae, both O1, O139, environmental and non O1/ non O139 such as V. anginiloticus, paraheamolytcus were incriminated in transferring resistance genes from one another. Antimimicrobial Susceptibility Testing phenotypic and Polymerase Chain Reaction (PCR) molecular procedure were employed in detecting the resistance and equally the use of Global Antimicrobial Surveillance System (GLASS) and Centre for Disease control (CDC) AR threat report 2019 was used successfully in the management of Vibrio cholerae epidemic. Conclusions: Drug-resistant Vibrio cholarae is a problem that needs to be dealt with as soon as possible ARTICLE HISTORY Received August 17, 2022 Accepted September 16, 2022 Published September 30, 2022 KEYWORDS Vibrio cholerae, Antibacterial Resistance, Mutation, Systematic Review. © The authors. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License (http://creativecommons.org/ licenses/by/4.0) 60