Journal of Pharmaceutical Negative Results ¦ Volume 13 ¦ Issue 4 ¦ 2022 1176 Study of specific properties of Polygonum Aviculare L. dry extract as a hemostatic agent Feruza Saydalieva, Ziyoda Fayzieva, Bahtigul Azimova, Nodirali Normakhamatov Tashkent pharmaceutical institute, 100015, Aybek Str.45, Tashkent Uzbekistan. E-mail: baxt_gulim@rocketmail.com Polygonum aviculare L., has been used in traditional medicine for many years. Hemostatic activity of the Polygonum aviculare L. dry extract (PADE) on the duration and amount of bleeding was studied in the current research. Moreover, the effect of the PADE was investigated on platelet count and capillary permeability. The results showed that the PADE administration increased platelet count by 212%, decreased retraction time by 50% and increased adhesive capacity by 225% and significantly reduced capillary permeability in the experimental animals. According to the results of this experiment, the Polygonum aviculare L. dry extract can be recommended to use in medical practice as a hemostatic agent in various hemorrhages. Keywords: Polygonum aviculare L., thrombin, adhesion, retraction, hemostatic drugs. INTRODUCTION Hemostasis is the natural process that leads to cessation of bleeding/ hemorrhage from a blood vessel in the body. The problem of the hemorrhage stopping very often demands an urgent crucial medical action. There are effective hemostatic agents, such as vitamin K (vicasol), calcium- containing drugs (calcium chloride, calcium gluconate and animal-derived of blood clotting factors) in the management of bleeding (Fatemeh 2020). Long-term use of chemical drugs such as hemostatic agents can cause adverse effects on the body. Herbs derived medicines from natural sources appear to be safe or no side effects. Investigations exploring the potential use of herbal medications should be encouraged and economically more favorable for patients. Hence, search for a medication with hemostatic and anti-inflammatory activities facilitating higher capillary permeability to be used in medical practice is of high value (Handan 2009, Ximena 2003). Polygonum aviculare L., also called knotweed a member of the Polygonaceae family, has been used in traditional medicine for the treatment of hemorrhage, diarrhea, dysentery, atherosclerosis, hemoptysis, and hemorrhoids, and as a coagulant and sedative treatment for many symptoms associated with hypertension, helps for inducing apoptosis in the breast cancer cell line MCF-7 (Sun 2014, Сhin-Yuan 2006, Habibi 2011, Yoon-Young 2013). Shepherd's purse also called Capsella bursa-pastoris is a well- known medicinal plant that commonly used in the traditional medicine for many purposes. According to the previous studies, Shepherd's purse preparations have a hemostatic, anticancer, analgesic and anti-inflammatory effects. Moreover, it is also used to control different types of bleeding (Ali Esmail 2015, Atieh 2019, Sahar 2017). Access this article online Quick Response Code: Website: www.pnrjournal.com DOI: 10.47750/pnr.2022.13.04.165 Address for correspondence: Bahtigul Azimova Tashkent pharmaceutical institute, 100015, Aybek Str.45, Tashkent Uzbekistan Email: baxt_gulim@rocketmail.com This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. For reprints contact: pnrjournal@gmail.com How to cite this article: Feruza Saydalieva, Ziyoda Fayzieva, Bahtigul Azimova, Nodirali Normakhamatov, Study of specific properties of Polygonum Aviculare L. dry extract as a hemostatic agent, J PHARM NEGATIVE RESULTS 2022;13: 1176-1180.