J Community Med Pub Health Res Ariana et al Vol 1, No 2, August 2020 Resistance Pattern Of Escherichia Coli 53 RESISTANCE PATTERN OF Escherichia Coli AGAINTS ANTIBIOTICS IN URINARY TRACT INFECTION PATIENTS IN RSUD DR. SOETOMO SURABAYA Novi Ariana 1 , Pestariati 2 , Retno Sasongkowati 2 , Debby Kusumaningrum 3 1 Student of Health Analyst, Politeknik Kesehatan Kemenkes Surabaya, 2 Department of Health Analyst, Politeknik Kesehatan Kemenkes Surabaya, 3 SMF Mikrobiologi, RSUD Dr.Soetomo Surabaya. ABSTRACT Pathogenic bacteria cause Urinary Infection imore or lessi about 85 - 95% are bacteria Escherichia coli. The treatment of Urinary Tract Infection (UTI) requires adequate supportive therapy and antibiotics, but antibiotic resistance is an obstacle in UTI treatment. This study aims to determine the types of antibiotics that are resistant to Escherichia coli in patients with UTI. This is an observational study with a descriptive method to determine the type of antibiotic-resistant to Escherichia coli in patients with UTI in the Laboratory of Clinical Microbiology RSUD Dr. Soetomo. Antibiotics that were resistant to Escherichia coli in UTI patients were cefazolin (80.49%), Amoxicillin Clavulanic Acid (73.17%), Ampicillin (73.17%), Tetracycline (68.29%), while antibiotics that were resistant to Escherichia coli ESBL was Amoxicillin Clavulanic Acid (100%), Ampicillin (100%), Cefazolin (99.7%), Aztreonam (99.7%), Ceftazidime (99.7%). The prevalence of Escherichia coli in UTI patients was 27.5%, while Escherichia coli ESBL was 72.5%. Based on the results of the research that has been obtained, it is better to do research on antibiotic resistance patterns periodically. Keywords : Urinary Tract Infection, Escherichia coli, antibiotics, ESBL Correspondence : Novi Ariana. Clinical Microbiology. Jl. Meyjen Prof. Dr. Moestopo 6-8 GDC lt.5 Mikrobiologi Klinik, Surabaya 081330104566. novi.mikrobiologi@gmail.com. INTRODUCTION Urinary Tract Infection (UTI) is an inflammatory response of the urothelial cells that line the urinary tract due to a bacterial infection characterized by bacteriuria and pyuria. 1 UTI is a common bacterial infection with an estimated 150 million patients every year worldwide. Surveillance studies in the United States reported 10.8 million patients attending UTI/year and 1.8 million patients (16.7%) hospitalized. Surveillance data with PPRA, Balitbangkes, WHO, in 2013 showed the prevalence of ESBL enzyme-producing bacteria in 6 Teaching Hospitals in Indonesia for Escherichia coli was 27-57% while Klebsiella pneumoniae was 32-56%. 2 The pathogenic bacteria that cause UTI are approximately 85-95% are Escherichia coli, and 5-20 % Enterobacteriaceae, Enterococcus and Staphylococcus. 3 The germ map of Dr. Soetomo Surabaya showed that the most common germs found in urine isolates were Eschericia coli (32.2%), Klebsiella