GUIDELINES 68 Ga-PSMA PET/CT: Joint EANM and SNMMI procedure guideline for prostate cancer imaging: version 1.0 Wolfgang P. Fendler 1,2 & Matthias Eiber 1,3 & Mohsen Beheshti 4 & Jamshed Bomanji 5 & Francesco Ceci 6 & Steven Cho 7 & Frederik Giesel 8 & Uwe Haberkorn 8 & Thomas A. Hope 9 & Klaus Kopka 10 & Bernd J. Krause 11 & Felix M. Mottaghy 12,13 & Heiko Schöder 14 & John Sunderland 15 & Simon Wan 5 & Hans-Jürgen Wester 16 & Stefano Fanti 6 & Ken Herrmann 1,17 # Springer-Verlag Berlin Heidelberg 2017 Abstract The aim of this guideline is to provide stan- dards for the recommendation, performance, interpreta- tion and reporting of 68 Ga-PSMA PET/CT for prostate cancer imaging. These recommendations will help to improve accuracy, precision, and repeatability of 68 Ga- PSMA PET/CT for prostate cancer essentially needed for implementation of this modality in science and rou- tine clinical practice. Keywords PSMA . PET . Prostate cancer . Staging . Restaging . Guideline Wolfgang P. Fendler and Matthias Eiber contributed equally to this work. Electronic supplementary material The online version of this article (doi:10.1007/s00259-017-3670-z) contains supplementary material, which is available to authorized users. * Ken Herrmann kherrmann@mednet.ucla.edu; ken.herrmann@uk-essen.de 1 Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, 10833 Le Conte Ave, 200 Medical Plaza, Los Angeles, CA, USA 2 Department of Nuclear Medicine, Ludwig-Maximilians-University of Munich, Munich, Germany 3 Department of Nuclear Medicine, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany 4 Department of Nuclear Medicine & Endocrinology, PET-CT Center, St. Vincent’ s Hospital, Linz, Austria 5 Institute of Nuclear Medicine, UCL/UCLH, London, UK 6 Nuclear Medicine Unit, University of Bologna, S. Orsola Hospital Bologna, Bologna, Italy 7 Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA 8 Department of Nuclear Medicine, University Hospital Heidelberg and DKFZ Heidelberg, Heidelberg, Germany 9 Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA 10 Division of Radiopharmaceutical Chemistry, German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany 11 Department of Nuclear Medicine, University Medical Center, University of Rostock, Rostock, Germany 12 Department of Nuclear Medicine, University Hospital RWTH Aachen University, Aachen, Germany 13 Department of Nuclear Medicine, Maastricht University Medical Center (MUMC+), Maastricht, The Netherlands 14 Memorial Sloan-Kettering Cancer Center, New York, NY, USA 15 Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, IA, USA 16 Pharmaceutical Radiochemistry, Technische Universität München, Walther-Meißner-Str.3, 85748 Garching, Germany 17 Klinik für Nuklearmedizin, Universitätsklinikum Essen, Hufelandstr. 55, 45147 Essen, Germany Eur J Nucl Med Mol Imaging DOI 10.1007/s00259-017-3670-z