Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jvh.13101 This article is protected by copyright. All rights reserved. PROF. CARLO FEDERICO PERNO (Orcid ID : 0000-0002-0825-5388) DR. VALENTINA SVICHER (Orcid ID : 0000-0002-2377-504X) Article type : Original Paper A snapshot of virological presentation and outcome of immunosuppression-driven HBV reactivation from real clinical-practice: evidence of a relevant risk of death and evolution from silent to chronic infection Romina Salpini 1* , Arianna Battisti 1* , Luna Colagrossi 1,2 , Domenico Di Carlo 1,3,4 , Lavinia Fabeni 1 , Lorenzo Piermatteo 1 , Carlotta Cerva 5 , Miriam Lichtner 6 , Claudio Mastroianni 6 , Massimo Marignani 7 , Sarah Maylin 8 , Constance Delaugerre 8 , Filomena Morisco 9 , Nicola Coppola 10 , Aldo Marrone 11 , Mario Angelico 12 , Loredana Sarmati 5 , Massimo Andreoni 5 , Carlo-Federico Perno 1,13§ , Francesca Ceccherini- Silberstein 1§ , Valentina Svicher 1§ 1 Tor Vergata University, Department of Experimental Medicine and Surgery, Rome, Italy 2 University of Milan, Department of Microbiology and Virology, Milan, Italy 3 University of Milan, Pediatric Clinical Research Center “Romeo and Erica Invernizzi”, Milan, Italy 4 University of Pavia, Department of Biology and Biotechnology, Pavia, Italy 5 Tor Vergata University Hospital, Infectious Diseases Unit, Rome, Italy 6 “Sapienza” University, Department of Public Health and Infectious Disease, Rome, Italy 7 “ S.Andrea” Hospital, Department of Digestive and Liver Disease, Rome, Italy 8 AP-HP Hopital Saint-Louis, Laboratoire de Virologie, Paris, France 9 University of Naples Federico II, Section of Infectious Diseases, Department of Clinical Medicine and Surgery, Naples, Italy 10 University of Campania “Luigi Vanvitelli”, Department of Mental Health and Public Medicine, Section of Infectious Diseases, Naples, Italy 11 University of Campania “Luigi Vanvitelli”, Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, Naples, Italy 12 Tor Vergata University Hospital, Hepatology Unit, Rome, Italy