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0143-3636 Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved. DOI: 10.1097/MNM.0000000000001225
Original article
Freeze-dried microspheres for selective intra-arterial
radionuclide therapy: an affordable solution
Jaya Shukla
a
, Naveen Kalra
b
, Bhagwant Rai Mittal
a
, Ajay Duseja
c
, Rajender
Kumar
a
, Harmandeep Singh
a
, Sreedhara Bettadahally Chaluvashetty
b
,
Madan Parmar
a
, Swathy Krishnan
a
, Ganesh Kumar
a
, Rakhee Vatsa
a
,
Anupriya Chhabra
a
, Kavita Bansal
a
, Yogesh Rathore
a
and Somit Pandey
a
Objective Selective intra-arterial radionuclide therapy
(SIRT) using radiolabelled microspheres is for the delivery
of therapeutic radioisotope to liver cancers and thus,
sparing healthy liver. Several radiolabelled microspheres
are commercially available. The main issue associated
with these microspheres is affordability. Re-188 is a
generator produced radionuclide, emits high energy
therapeutic beta particle and imageable gamma photons
for pre- and post-therapy dosimetry.
Methods Tc-99m/Re-188 labelled microspheres have
been developed and quality control tests have been
performed for suitable clinical use. The clinical studies
with Re-188 microspheres for SIRT have been performed.
Post-therapy images were acquired for dosimetry.
Results The microspheres were found to possess
spherical morphology of less than 20 μm size. The
quality control revealed the suitability of microspheres
for intravenous administration. The preliminary studies in
thirty patients demonstrated good retention in tumor and
high tumor to normal liver ratio. Re-188 microspheres
were well tolerated by patients. Same microspheres
labelled with either Tc-99m or Re-188 were used for
pretherapy dosimetry and Re-188 labeled microspheres
for therapy (SIRT) as a single-day procedure.
Conclusion The freeze-dried microspheres may
emerge as highly cost-effective candidates for both
pre-therapy dosimetry and SIRT and may benefit a large
population with inoperable liver cancer. Nucl Med Commun
41: 817–823 Copyright © 2020 Wolters Kluwer Health, Inc.
All rights reserved.
Nuclear Medicine Communications 2020, 41:817–823
Keywords: hepatocellular carcinoma, liver cancer, locoregional treatment,
selective intraarterial radionuclide therapy
Departments of
a
Nuclear Medicine and PET,
b
Radiodiagnosis and Imaging
and
c
Hepatology, Post Graduate Institute of Medical Education and Research,
Chandigarh, India
Correspondence to Jaya Shukla, PhD, Department of Nuclear Medicine and
PET, Post Graduate Institute of Medical Education and Research Chandigarh
160012, India
Tel: +91 172 2756722; fax: +91 172 2742858; e-mail: shuklajaya@gmail.com
Received 2 February 2020 Accepted 30 April 2020
Introduction
Liver cancer is ffth for men and seventh for women
cause of death worldwide [1,2]. Hepatocellular carcinoma
(HCC), a tumor of hepatocytes, is the primary liver cancer
comprising 75–85% liver cancer cases with predominance
in Asia and Africa. The major causes of HCC include
chronic infection with hepatitis B virus, hepatitis C virus,
alcoholic liver disease, obesity, type 2 diabetes mellitus,
nonalcoholic fatty liver disease, afatoxin-contaminated
food, smoking, and genetics. Liver is also a common
metastatic site of several primary tumors like neuroen-
docrine tumors, bladder cancer, and colorectal cancers
[3]. Surgical modalities including hepatic resection and
liver transplantation are curative options in patients
with HCC but are limited to only a select group of
patients. Several nonsurgical curative treatment options
like radio-frequency ablation, microwave ablation, high
intensity focused ultrasound ablation, and cryotherapy
are available for patients in the early stage of the disease.
Most of the patients in intermediate stage who are not ft
for surgical or non-surgical curative modalities are treated
with palliative modalities like transarterial chemoembo-
lization, or radioembolization and selective intra-arterial
radionuclide therapy (SIRT) [4–6].
Trans- or intra-arterial therapies exploit the unique dual
blood supply to liver. Normal hepatocytes receive major
blood supply from portal vein (~80%) and rest by hepatic
artery. However, hepatic artery is a major feeding vessel
for liver cancer. The liver is radiosensitive organ, but,
most of the healthy liver is spared if the therapy to liver
cancers is given via hepatic artery. Therefore, delivery
of therapeutic radioisotope via hepatic artery is a suita-
ble option to treat liver cancer. Several isotope carriers
like lipiodol, resin, glass beads, and spheres have shown
suitability for treatment of liver cancer. However, it is
important to note that if the portal vein is thrombosed,