Antioxidant and nephroprotection activities of Combretum micranthum:A phytochemical, in-vitro and ex- vivo studies Mabozou Kpemissi a, b, c, * , Kwashie Eklu-Gadegbeku a , Veeresh P. Veerapur c , Adrian-Valentin Pot^ arniche b , Kodjo Adi a , S. Vijayakumar c , Siddalingesh M. Banakar d , N. V. Thimmaiah d , Kossi Metowogo a , Kodjo Aklikokou a a Faculty of Sciences, University of Lom e, Togo b University of Agricultural Science and Veterinary Medicine, Manastur Street. 3-5, 400372, Cluj-Napoca, Romania c Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur 572 102, Karnataka, India d Anthem Biosciences Pvt. Ltd., Industrial Area Phase I, Bommasandra, Hosur Road, Bangalore, 560099, India * Corresponding author. E-mail address: mabozou@gmail.com (M. Kpemissi). Abstract Management of chronic renal failure is exceedingly expensive. Despite of encouraging experimental outcomes, there is a lack of potent nephroprotective drugable molecules in a clinics or market. To develop a nephroprotective phytomedicine, the present study was designed to do a literature survey on reported phytochemical and biological analysis of Combretum micranthum and to carry out chemoprofiling, in-vitro antioxidant and ex-vivo nephroprotective capacity of the title plant. The phytochemical and biological activity survey of C. micranthum has reveals the presence of many bioactive compounds such as flavonoids, terpenoids, steroids and alkaloids with many biological activities. Phytochemical investigation re-confirmed the presence of these compounds. Hydroalcoholic extract of C. micranthum (CM extract) showed a strong antioxidant activity by scavenging AAPH, DPPH, nitric oxide, hydrogen Received: 20 October 2018 Revised: 21 January 2019 Accepted: 13 March 2019 Cite as: Mabozou Kpemissi, Kwashie Eklu-Gadegbeku, Veeresh P. Veerapur, Adrian-Valentin Pot^ arniche, Kodjo Adi, S. Vijayakumar, Siddalingesh M. Banakar, N. V. Thimmaiah, Kossi Metowogo, Kodjo Aklikokou. Antioxidant and nephroprotection activities of Combretum micranthum:A phytochemical, in-vitro and ex-vivo studies. Heliyon 5 (2019) e01365. doi: 10.1016/j.heliyon.2019. e01365 https://doi.org/10.1016/j.heliyon.2019.e01365 2405-8440/Ó 2019 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).