and  4.4 on day 3 reached a sensitivity of 88% and 90% respectively and a specificity of 60% for both in prediction of severe AP. Conclusion: NRL ratio is a simple, inexpensive and available tool to stratify patients with AP. P3-197. All-in. Parturition, birth, MRCP and cholecystectomy in the early phase of biliary pancreatitis in a 36 weeks pregnant woman: a case report L aszl o Gajd an 1 ,  Agnes S ark any 2 , Katalin M arta 1 ,  Aron Altorjay 3 , Viola Zsuzsanna Kellner 4 , Erika Kiss 5 ,B alint Gy€ orgy 2 , Peter Hegyi 1 , Izb eki Ferenc 1 1 Centre for Translational Medicine, University of P ecs e Szent Gy€ orgy Teaching Hospital of County Fej er, Sz ekesfeh erv ar, Hungary 2 Division of Central Anaesthesiology and Intensive Care Unit, Szent Gy€ orgy Teaching Hospital of County Fej er, Sz ekesfeh erv ar, Hungary 3 Division of Surgery, Szent Gy€ orgy Teaching Hospital of County Fej er, Sz ekesfeh erv ar, Hungary 4 Synlab Laboratory, Szent Gy€ orgy Teaching Hospital of County Fej er, Sz ekesfeh erv ar, Hungary 5 Division of Radiology, Szent Gy€ orgy Teaching Hospital of County Fej er, Sz ekesfeh erv ar, Hungary Objectives Introduction: A Pancreatic Centre was established in a county hospital on 01.03.2018 in order to provide specialized care for pa- tients suffering from pancreatic diseases. One week after the opening of the Pancreatic Centre a pregnant woman presented with acute biliary pancreatitis (ABP). Acute pancreatitis in pregnancy makes the manage- ment of the disease very challenging, due to limited diagnostic and ther- apeutic options, while complications can harm both the mother and the baby. Aim: Here we report a case of a 36 weeks pregnant woman who pre- sented with ABP in our newly established Pancreatic Centre. Methods The consensus-based CARE guideline for standardizedclinical case reporting was followed. Results The 26-year-old woman had 2 previous uncomplicated preg- nancies and births. Prior to her admission with ABP she had 5 months history of recurrent, episodic, post prandial, right upper quadrant pain with occasional vomiting. Biliary colic was diagnosed after ultrasonogra- phy confirmed stones in the gall bladder. The patient did not need hospital admission and conservative management was suggested. In this index admission she presented to the emergency unit with 2 hours of epigastric pain radiating to her back, which was dissimilar to her previous biliary colic. Blood tests confirmed acute pancreatitis (amilase: 581 U/l, lipase: 1765 U/l).Ultrasonography showed stones in the gall bladder, but no cholecystitis or dilated biliary tree. A BISAP score of 0 on admission predicted mild pancreatitis (CN: 3.3 mmol/l, no altered mental state, no SIRS criteria, age 26 years, no pelural effusion). After conservative management was commenced, the symptoms of ABP quickly resolved and parturition started 6h after admission. A healthy baby was born 4 hours later. On day 2 the serum pancreatic enzyme levels were normal again and the abdominal pain resolved. Oral feeding was started and an MRCP was indicated to exclude dilation of the biliary system or stones in the common bile duct. Laparoscopic cholecystectomy was performed on day 3. The patient was discharged on day 4 to maternity ward. Conclusion Parturition and birth does not modify the outcome of acute pancreatitis. The multidisciplinary team in a Pancreatic Centre provides and adequate a very quick management of pancreatitis patients, therefore, our case is a very good example of the necessity of centralized medical care for patients suffering from AP. P3-023. Sarcopenia is a common complication of chronic pancreatitis and as- sociates with increased hospitalization rates and reduced survival Søren Schou Olesen 1 , Alev Büyükuslu 2 , Marianne Køhler 3 , Henrik Højgaard Rasmussen 3 , Asbjørn Mohr Drewes 2 1 Aalborg University Hospital, Centre for Pancreatic Diseases, Department og Gastroenterology and Hepatology, Aalborg, Denmark 2 Aalborg University Hospital, Centre for Pancreatic Diseases, Department of Gastroenterology and Hepatology, Aalborg, Denmark 3 Aalborg University Hospital, Centre for Nutrition and Bowel Disease, Department of Gastroenterology and Hepatology, Aalborg, Denmark Objectives Malnutrition is a well-known complication of chronic pancreatitis and alterations in body composition and metabolic adaption are common in this context. Consequently, patients have an increased risk of progressive loss of skeletal muscle mass and function (sarcopenia). We investigated the prevalence of sarcopenia in patients with chronic pancreatitis, its associated risk factors and health-related outcome. Methods This was a prospective, monocentric study of chronic pancreatitis outpatients. We used bioelectric impedance to measure body composition, and a handheld dynamometer (hand grip strength) and the timed up and go test to investigate muscle function. In addition, patients were classified using conventional anthropometric parameters (weight, height, and body mass index ([BMI]). Sarcopenia was defined according to international consensus criteria. Several parameters including aetiology of chronic pancreatitis, exocrine pancreatic insufficiency (EPI), smoking, and pain related symptoms were analysed for their association with sarcope- nia. The EORCT QLQ-C30 questionnaire was used to document life quality. In addition, we investigated associations between sarcopenia and number of hospital admissions, number of in-hospital days and survival over the next 12 months. Results A total of 186 patients with chronic pancreatitis were enrolled in the study. The median age was 57.7 years (IQR 49.1-65.6), 68% were men, and 55% had an alcoholic aetiology. The prevalence of sarcopenia was 18.3% (95% CI; 13.0-24.6). An abnormal low BMI (< 18.5 kg/m2) was seen in 29% of sarcopenic patients, while 71% had a BMI in the normal or over- weight range. Sarcopenia was significantly associated with EPI, opioid treatment and smoking on univariate analysis. Multivariate analysis confirmed the independence and significance of the association for EPI (OR 4.1 95% CI [1.1-15.1]; p¼0.03). Several QOL scales and items were associated with sarcopenia including physical functioning (p<0.001) and global health (p¼0.006). During follow-up, sarcopenia was associated with increased hospital admission rates (p¼0.03), increased number of in- hospital days (p<0.001) and reduced survival (HR 7.3 [95% CI; 2.1-26.0]; p¼0.002]). Conclusion Sarcopenia is a common complication of chronic pancre- atitis, but in the majority of patients it is not recognised by conventional anthropometric parameters. As sarcopenia is associated with adverse health-related outcome, systematic evaluation of this common complica- tion should be prioritized. P3-025. Alcohol excess and continued smoking are risk factors for progression from minimal change chronic pancreatitis to established chronic pancreatitis Andrea Sheel 1, 2 , Ryan Baron 1,2 , Jayapal Ramesh 3 , Paula Ghaneh 1, 2 , Michael Raraty 1, 2 , Vincent Yip 1 , Robert Sutton 1, 2 , Fiona Campbell 4 , Ammad Farooq 5 , Christopher Halloran 1, 2 , John Neoptolemos 6 Abstracts / Pancreatology 18 (2018) S1eS188 S103