A38 Abstracts 359 Febrile seizures in family history M KNEZEVIC-POGANCEV, S BELESLIN, G BISTRICIC, A SREK Institute for Children and Youth Health Care - Novi Sad Medical Center “Kosta Sredojev Sljuka” - Kikinda Yugoslavia Febrile seizures, being one of the most dramatic states in children and practically the most frequent neurologic disorder in children, although benign in course and prognosis, cause a great deal of stress because they occur in the family, often in several members of the same family. During 5-year period, 456 children with atypical febrile seizures were followed; 54.82% boys and 45.18% girls (87.06% children) had repeated attacks. Febrile seizures had occurred in both parents in 78.29%; in one parent in 47.37%; in siblings in 35.96% (41.66% children were the first born child in the family). Close relatives had febrile seizures in 68.42%, and distant relatives in 61.40% of cases. Compared with children observed for other reasons (epilepsy, cephalgia), there is statistically significant difference for occurrence of febrile seizures in parents and siblings, but not for their occurrence in close and distant relatives. 361 A contribution to the genetics of benign partial epilepsy with centro-temporal spikes M KNEZEVIC-POGANCEV, A SREK Institute for Children and Youth Health Care - Novi Sad, Yugoslavia Spontaneous and sleeping EEG were recorded in siblings of patients with repeated attacks of benign partial epilepsy with centro-temporal spikes. Non-specific discharges and high comition readiness was noted in 57% of siblings. Specific discharges (centro- temporal spikes) were noted exclusively in the walking state only in 3% of siblings, in sleepiness and waking after sleep deprivation in 35%, and only in sleep after sleep deprivation in 5% of siblings. The greatest number of specific discharges occurred during waking EEG after sleep deprivation in siblings aged 8-15 years. During following period of 5 years, 13% of those siblings experienced partial seizures. 258 Frontal lobe status epilepticus with severe morbidity ] KdBOR, 7,2 A ABUTALEB’ ‘Department of Paediatrics, Albert Szent-Gytirgyi Medical University, Szeged, Hungary, ‘Department of Paediatrics, King Fahad National Guard Hospital, Riyadh, Saudi Arabia As severe morbidity or mortality is a very rare conse- quence, aggressive treatment for complex partial status epilepticus (SE) is only rarely recommended. A 2?$year- old boy with severe neurological residua after a complex partial SE is presented. He started to have recurrent attacks at the age of 8 months that repeated weekly or monthly in spite of phenobarbital or carbamazepine therapy. Interictal EEG examinations revealed no significant abnormality on several occasions. After a mildly delayed psychomotor development, he presented with an SE at the age of 2 years. On examination he was found lying supine, screaming and produced tonic posturing with the head turned to the left, left arm extended and the right one flexed and he did not respond to verbal or visual stimuli. These episodes were repeated lo-15 minutes apart without him regaining consciousness in between. On ictal EEG, bifrontal rhythmic 3Hz slow or sharp-and-slow dis- charges were seen, more so on the right. Fundoscopy, cranial CT and MRI, cerebrospinal fluid and metabolic work-up did not reveal any abnormality. Though diazepam, lorazepam, phenytoin, phenobarbital and continuous midazolam infusion were given successively, the attacks did not come under control. Finally, two courses of thiopental infusion were given, the last one for 3 days. As a result, both the clinical seizures and the electric epileptic discharges ceased. The patient recov- ered only very slowly, 6 months after the status a left side weakness was still obvious. This child apparently had a partial SE, and based on the unresponsiveness it was a complex partial one, most probably involving the right supplementary motor area. Although it is difficult to say how he would have done without thiopental, as an underlying severe cause or vegatative-metabolic crisis did not play a role in our patient’s residua, we conclude that rare cases with complex partial SE may need as aggressive therapy as those with the generalized convulsive forms. Though highly desirable, it is difficult to outline a subgroup of complex partial SE patients for whom the need for this approach can be anticipated. 093 Somatosensory evoked high-frequency oscillations in a patient with benign rolandic epilepsy MASAYA KUBOTA, KAZUHIDE TAKESHITA, SOH ATSUMI, HIROSHI ICHISEKI, MICHIAKI NACURA, HIROYUKI HIROSE, YOICHI SAKAKIHARA, MASAYOSHI YANAGISAWA Department of Paediatrics, The University of Tokyo, Japan Age-related generator mechanism of rolandic discharges in patients with benign rolandic epilepsy is not yet clarified. We here analysed somatosensory evoked high- frequency oscillations (HFO) in a 12-year-old boy with benign rolandic epilepsy using a 37-channel magnet- ometer (BTi) to study the role of GABAergic inhibitory interneurons in generator mechanism of rolandic discharges. Patient report: This 12-year-old boy developed ankle myoclonus during early light sleep at the age of 5 years. He also had sylvian seizures. In EEG, rolandic discharges were found in the bilateral centroparietal area with left predominancy, which were activated by sleep and occasionally coupled with myoclonus. The fre- quency of the nocturnal myoclonus and sylvian seizures had reduced spontaneously since he was 9 years old without medication. He was diagnosed as