Research Article Neuropharmacological and Antidiabetic Potential of Lannea coromandelica (Houtt.) Merr. Leaves Extract: An Experimental Analysis FahadulIslam , 1 SaikatMitra, 2 MohamedH.Nafady , 3 MohammadTauhidurRahman, 4 Vineet Tirth, 5,6 Aklima Akter, 1 Talha Bin Emran , 7 Amany Abdel-Rahman Mohamed , 8 Ali Algahtani , 5,6 and Sanad S. El-Kholy 9 1 Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh 2 Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh 3 Faculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt 4 Department of Cardiology, Z.U Model Hospital, Feni 3900, Bangladesh 5 Mechanical Engineering Department, College of Engineering, King Khalid University, Abha 61421, Asir, Saudi Arabia 6 Research Center for Advanced Materials Science (RCAMS), King Khalid University, Guraiger, Abha 61413, Asir, P.O. Box No. 9004, Saudi Arabia 7 Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh 8 Department of Forensic Medicine and Toxicology, Zagazig University, Zagazig 44511, Egypt 9 Department of Physiology, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt Correspondence should be addressed to Talha Bin Emran; talhabmb@gmail.com Received 10 February 2022; Revised 25 February 2022; Accepted 28 February 2022; Published 28 March 2022 Academic Editor: Fernanda Tonelli Copyright © 2022 Fahadul Islam et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. e present study examines the neuropharmacological and antidiabetic properties of methanol leaves extract of Lannea coromandelica in animal models. is study is carried out by elevated plus-maze apparatus, motor coordination, thiopental sodium has an induction role in sleeping time, hole board, hole cross, open field, antidiabetic studies. Mice were treated doses of 100, 150, and 200 mg/kg body weight in elevated plus-maze apparatus and motor coordination; 100 and 200 mg/kg body weight in sleeping time, hole cross, hole board, and open field tests; and 200 and 400 mg/kg body weight in the antidiabetic activity test. Extraction specifies a significantly decreased time duration and sleeping time in a thiopental sodium-induced sleeping time test. e experimental extract decreased locomotor and exploratory behaviors of mice in the open-field and hole-cross tests compared to the effects of the control. Furthermore, the extract increased sleeping time with a dose-dependent onset of action. e hole- board test extract also demonstrated a reduced number of head dips. e findings showed that L. coromandelica has potential neuropharmacological effects. In addition, in alloxan-induced diabetic mice, leaves extract at 200 and 400 mg/kg body weight revealed significant antidiabetic properties and could be used to manage blood glucose levels with more research. 1. Introduction A stressful lifestyle has recently been connected to several neurological disorders, indicating that depression is an apparent medical problem in these disorders [1–4]. Anti- psychotic agents such as tricyclic antidepressants (TCAs), monoamine oxidase inhibitors (MAOs), and selective se- rotonin reuptake inhibitors (SSRIs) are available to treat various psychotic disorders. Still, their long-term employ- ment is being hindered by several unwanted side effects [5, 6]. erefore, exploring novel anxiolytic agents with low detrimental consequences is still ongoing for a suitable Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2022, Article ID 6144733, 10 pages https://doi.org/10.1155/2022/6144733