Jurnal Kimia Valensi, Vol 8(1), May 2022, 106-112 Available online at Website: http://journal.uinjkt.ac.id/index.php/valensi Copyright©2022, Published by Jurnal Kimia Valensi P-ISSN: 2460-6065, E-ISSN: 2548-3013 A Nortriterpenoid and Steroid from the Stem Bark of Aglaia angustifolia Miq (Meliaceae) Ricson Pemimpin Hutagaol 1 , Ihsan Rahadian 2 , Desi Harneti 2 , Ace Tatang Hidayat 2,3 , Khalijah Awang 4 , Yoshihito shiono 5 , Srikandi Srikandi 1 , Unang Supratman 2,3* 1 Department of Chemistry, Faculty of Mathematics and Natural sciences, Nusa Bangsa University, Bogor 16166, Indonesia. 2 Department of Chemistry, Faculty of Mathematics and Natural sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia. 3 Central Laboratory of Universitas Padjadjaran, Jatinangor 45363, Indonesia 4 Department of Chemistry, Faculty of Sciences, University of Malaya, Kuala Lumpur 59100, Malaysia. 5 Department of Food, Life and Environment Science, Faculty of Agriculture, Yamagata University, Yamagata,997-8555, Japan. *Corresponding author: unang.supratman@unpad.ac.id Received: November 2021; Revision: December 2022; Accepted: March 2022; Available online: May 2022 Abstract A nortriterpenoid, 3-epi-cabraleahydroxylactone (1) and a steroid, stigma-4-en-3-on (2) were isolated from the n- hexane extract of stem bark of Aglaia angustifolia Miq. Compound (2) was isolated for the first time from this Genus. The structure of both compounds were identified by spectroscopic datas including one and two- dimensional NMR as well as infrared spectrum, high-resolution mass spectrometric analysis and by comparing with those spectral data previously. Keywords: Aglaia angustifolia, Cabraleahydroxylactone, Stigmastane, Nortriterpenoid. DOI: 10.15408/jkv.v8i1.23011 1. INTRODUCTION Aglaia, the largest genus of subtropical and tropical angiosperm family of Meliaceae, consists of 130 species distributed mainly in the Southern mainland China, Indo-Malaysian region and the Pacific Island (Mabberley & Pannel, 1995), (Inada et al., 2001). Meliaceae is a family known for the presence of triterpenes with interesting biological activities, such as hypoglycemia, anticancer, anti-inflammatory, antifeedant, insecticides, and antitumor activities. The plants genus Aglaia has been found to yield a variety of different classes of compounds such as triterpenoid, lignans, rocaglate derivatives, sesquiterpenoids, tetraterpenoids and steroids (Liu et al., 2014); (Weber et al., 2000); (Pan et al., 2010). Aglaia angustifolia (Miq.) species mainly distributed in Indonesia (Sumatera, Kalimantan islands) and declared almost extinct (Pannel, 1992). We found that A. angsutifolia (Miq.) has not done much phytochemical research. The course of our continuous investigation for biologically active compounds from Indonesian Aglaia plants, we already isolated several active compounds from A. Smithii (Harneti et al., 2012); A. eximia (Harneti et al., 2014); (Sianturi, et al., 2015a); (Sianturi, et al., 2015b); A. argentea (Farabi, et al., 2017a); (Farabi, et al., 2017b); A. elliptica (Farabi et al., 2018), (Hidayat et al., 2017) and recently A. angustifolia (Hutagaol et al., 2021); (Hutagaol et al., 2020a) (Hutagaol, et al., 2020b). In this paper, we report the isolation and structural elucidation of a nortriterpenoid, 3- epi-cabraleahydroxylacton, and a steroid stigmast-4-en-3-on which to our knowledge is a new type-steroid compound found in Aglaia genus. 2. MATERIAL AND METHODS General IR spectra were measured on a Perkin Elmer 1760 X FT-IR in potassium bromide