Accepted Manuscript Optimizing Outcomes of Treatment Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized Pilar Cristancho MD , Emily Lenard MSW , Eric J Lenze MD , J. Philip Miller AB , Patrick J. Brown PhD , Steven P. Roose MD , Carolina Montes-Garcia BA , Daniel M. Blumberger MD, MSc, FRCPC , Benoit H. Mulsant MD, MS , Helen Lavretsky MD , Bruce L. Rollman MD, MPH , Charles F. Reynolds III MD , Jordan F. Karp MD PII: S1064-7481(19)30338-0 DOI: https://doi.org/10.1016/j.jagp.2019.04.005 Reference: AMGP 1243 To appear in: The American Journal of Geriatric Psychiatry Please cite this article as: Pilar Cristancho MD , Emily Lenard MSW , Eric J Lenze MD , J. Philip Miller AB , Patrick J. Brown PhD , Steven P. Roose MD , Carolina Montes-Garcia BA , Daniel M. Blumberger MD, MSc, FRCPC , Benoit H. Mulsant MD, MS , Helen Lavretsky MD , Bruce L. Rollman MD, MPH , Charles F. Reynolds III MD , Jordan F. Karp MD , Optimizing Out- comes of Treatment Resistant Depression in Older Adults (OPTIMUM): Study Design and Treatment Characteristics of the First 396 Participants Randomized, The American Journal of Geriatric Psychiatry (2019), doi: https://doi.org/10.1016/j.jagp.2019.04.005 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.