Open Journal of Pediatrics, 2021, 11, 339-350 https://www.scirp.org/journal/ojped ISSN Online: 2160-8776 ISSN Print: 2160-8741 DOI: 10.4236/ojped.2021.113031 Jul. 15, 2021 339 Open Journal of Pediatrics Epileptic Encephalopathies in Infants and Children: Study of Clinico-Electroencephalographic Spectrum in a Tertiary Hospital in Bangladesh Bithi Debnath 1* , Rajib Nayan Chowdhury 2 , Narayan Chandra Shaha 1 , Mohammad Enayet Hussain 2 1 Department of Paediatric Neurology, National Institute of Neurosciences and Hospital, Sher-E-Bangla Nagar, Dhaka, Bangladesh 2 Department of Neurophysiology, National Institute of Neurosciences and Hospital, Sher-E-Bangla Nagar, Dhaka, Bangladesh Abstract Background: The epileptic encephalopathies collectively exact an immense personal, medical, and financial toll on the affected children, their families, and the healthcare system. Objective: This study was aimed to delineate the clinical spectrum of patients with Epileptic encephalopathies (EEs) and clas- sify them under various epileptic syndromes. Methods: This was a cross-sectional study that was carried out in the department of Neurophysi- ology of the National Institute of Neurosciences and Hospital, Bangladesh from July 2016 to June 2019. Children with recurrent seizures which were dif- ficult to control and associated with developmental arrest or regression in absence of a progressive brain pathology were considered to be suffering from EE. Children under 12 years of age fulfilling the inclusion criteria were enrolled in the study. These patients were evaluated clinically and Electroen- cephalography (EEG) was done in all children at presentation. Based on the clinical profile and EEG findings the patients were categorized under various epileptic syndromes according to International League Against Epilepsy (ILAE) classification 2010. Results: A total of 1256 children under 12 years of age were referred to the Neurophysiology Department. Among them, 162 (12.90%) fulfilled the inclusion criteria. Most of the patients were male (64.2%) and below 1 year (37.7%) of age. The majority (56.8%) were delivered at the hospital and 40.1% had a history of perinatal asphyxia. Development was age-appropriate before the onset of a seizure in 38.9% of cases. Most (53.7%) of the patients had seizure onset within 3 months of age. Categoriza- tion of Epileptic syndromes found that majority had West Syndrome (WS) How to cite this paper: Debnath, B., Chowdhury, R.N., Shaha, N.C. and Hus- sain, M.E. (2021) Epileptic Encephalopa- thies in Infants and Children: Study of Clinico-Electroencephalographic Spectrum in a Tertiary Hospital in Bangladesh. Open Journal of Pediatrics, 11, 339-350. https://doi.org/10.4236/ojped.2021.113031 Received: June 1, 2021 Accepted: July 12, 2021 Published: July 15, 2021 Copyright © 2021 by author(s) and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY 4.0). http://creativecommons.org/licenses/by/4.0/ Open Access