ABSTRACT Objective: To correlate Uroflowmetry with Prostate volume and International Prostatic Symptom Score in BPH patients and healthy adults in a subset of Karachi Population. Study Design and Setting: This is a crossectional study carried out at Ziauddin Hospital, Karachi over a period of 6 months. Methodology: In this study 100 Samples were taken through non probability convenience sampling. Inclusion criteria includes 40years and above. Sample initially was taken on the basis of International Prostatic Symptom Score i.e., less than 8 and greater than 8 score. Ultrasonography was performed. 65 Individuals with International Prostatic Symptom Score > 8 and Prostate volume <25 and individuals having symptom index < 8 and Prostate volume > 25ml went for Uroflowmetry. Mean and standard deviation was taken out for quantitative variables. Univariate analysis and Multiple Linear Regression applied to assess relationship between Uroflowmetry with Prostate volume and International Prostatic Symptom Score. Result: Mean age of patients was found to be 58±6 years. Mean International Prostatic Symptom Score was 11±4. Mean Prostate Volume was 28ml±5, mean Qmax was 14ml/s ±4. The correlation between Qmax and International Prostatic symptom score was found to be negative (-0.78) and statistically significant. No correlation was found between Prostate volume and Qmax. Conclusion: Qmax and International Prostatic Symptom Score are reliable tool for assessing Benign Prostatic Hyperplasia patients concluding that as Symptom Score increases Qmax decreases. Qmax showed no correlation with Prostate volume. Prostate volume assessed on Ultrasonography is not an authentic parameter for diagnosing BPH patients. Keywords: International Prostatic Symptom Score (IPSS), Prostate volume (PV), Lower Urinary Tract Symptoms (LUTS), Uroflowmetry (UFM), Qmax (peak flow measurement) Correlation of Uroflowmetry with Prostate Volume and International Prostatic Symptom Score (IPSS) How to cite this Article: Raza I, Jamshed N, Kakhani M, Mohiuddin M, Ahmed SB Mukhtar S. Correlation of Uroflowmetry with Prostate Volume and International Prostatic Symptom Score (IPSS). J Bahria Uni Med Dental Coll. 2022; 12(4):191-6. DOI: https://doi.org/10.51985/JBUMDC202242 Original Article Open Access Iffat Raza, Nausheen Jamshed, Mubina Lakhani, Maria Mohiuddin, Syeda Bushra Ahmed, Sahrish Mukhtar This is an Open Access article distributed under the terms of the Creative Commons Attribution Non Commercial License (http:// creativecommons/org/licences/by-nc/4.0) which permits unrestricted non commercial use, distribution and reproduction in any medium, provided the original work is properly cited. INTRODUCTION: Benign Prostatic Hyperplasia, the most frequently occurring disease among aged males of 40 to 80 years 1 . It is important to evaluate prostate volume of individuals with BPH that have symptoms of lower urinary tract as if it is not treated timely will worsen the condition leading towards Urinary Retention. Prostate Volume (PV) is important predictor as well as prognostic factor for minimally invasive Transurethral Prostatectomy and open prostatectomy 2 . In order to diagnose BPH, prostate volume assessed by Transabdominal Ultrasonography (TAUS) was the most easily available and accessible parameter, however reliability was always a concern, thus Transrectal Ultrasonography (TRUS) is usually considered as gold standard for diagnosing BPH 3 . Uroflowmetry (UFM) is a simple, noninvasive procedure that measures the flow rate of voided urine. Its use has become clinically widespread. Turner Warwick was the first to demonstrate how I/V urogram can be replaced into a urodynamic study 4 . It measures the flow of urine during Iffat Raza (Corresponding Author) Associate Professor, Department of Anatomy Karachi Institute of Medical Sciences Email: Razaiffat2@gmail.com Nausheen Jamshed Assistant Professor, Department of Anatomy Karachi Institute of Medical Sciences Mubina Lakhani Assistant Professor, Department of Anatomy Ziauddin University Maria Mohiuddin Assistant Professor, Department of Anatomy Hamdard College of Medicine and Dentistry Syeda Bushra Ahmed Assistant Professor Department of Anatomy Hamdard College of Medicine and Dentistry Sahrish Mukhtar Associate Professor, Department of Anatomy Jinnah Medical and Dental College Received: 24-Mar-2022 Accepted: 16-Sep-2022 Page-191 JBUMDC 2022;12(4):191-196