https://doi.org/10.1177/0269215519880235 Clinical Rehabilitation 1–8 © The Author(s) 2019 Article reuse guidelines: sagepub.com/journals-permissions DOI: 10.1177/0269215519880235 journals.sagepub.com/home/cre CLINICAL REHABILITATION Intradialytic exercise with blood flow restriction is more effective than conventional exercise in improving walking endurance in hemodialysis patients: a randomized controlled trial Rodrigo Kohn Cardoso 1 , Aline Machado Araujo 1 , Fabrício Boscolo Del Vechio 1 , Maristela Bohlke 2,3 , Franklin Correa Barcellos 2 , Jean Pierre Oses 3 , Matheus Pintanel de Freitas 1 and Airton José Rombaldi 1 Abstract Objective: This study aims to compare the effect of intradialytic aerobic exercise with blood flow restriction, without blood flow restriction (conventional) and no exercise (control) on muscle strength and walking endurance among chronic kidney disease patients. Design: Open label and parallel group randomized controlled trial. Subjects: Adult patients with chronic kidney disease on hemodialysis. Intervention: A 12-week intradialytic training with or without blood flow restriction compared with a control group. Main measures: Strength and walking endurance were measured using thoracolumbar dynamometry and a 6-minute walk test, respectively, before and after training. Results: A total of 66 patients were randomized into three groups: blood flow restriction group (n = 22), conventional exercise group (n = 22) and control group (n = 22). There were seven dropouts, and 59 patients were included in the analysis. There was a significant increase in the 6-minute walking distance in the blood flow restriction group (from 412.7 (115.9) to 483.0 (131.0) m, P = 0.007) in comparison with the conventional exercise group (from 426.79 (115.00) to 433.2 (120.42) m, not significant) and the control group (from 428.4 (108.1) to 417.3 (100.2) m, not significant). The change in the walking distance over time was significantly different among groups (intervention group/time, P = 0.02). The simple effects test 1 Postgraduate Program of Physical Education, Federal University of Pelotas, Pelotas, Brazil 2 Dialysis and Renal Transplantation Unit, São Francisco de Paula University Hospital, Catholic University of Pelotas, Pelotas, Brazil 880235CRE 0 0 10.1177/0269215519880235Clinical RehabilitationCardoso et al. research-article 2019 Original Article 3 Postgraduate Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Brazil Corresponding author: Rodrigo Kohn Cardoso, Postgraduate Program of Physical Education, Federal University of Pelotas, Pelotas 96010-610, Brazil. Email: rodrigokohn21@yahoo.com.br