RADIATION ONCOLOGY
932
Providing MR Imaging for Cervical
Cancer Brachytherapy: Lessons for
Radiologists
1
Brachytherapy (BT), the use of a locally placed or implanted radio-
active source for treatment of an adjacent tumor, is an important
component in the treatment of patients with both early- and ad-
vanced-stage cervical cancer and is increasingly part of the standard
treatment protocol. When it is feasible, many radiation oncologists
choose to include a magnetic resonance (MR) imaging examina-
tion for planning BT treatment (ie, an MR imaging examination
after placement of the applicator but before radiation dosing). MR
imaging provides excellent soft-tissue contrast and allows radiation
oncologists to individualize the radiation dose to the target volume
and minimize the dose to adjacent organs that are at risk for radia-
tion damage. However, traditionally, the radiology department has
not performed imaging studies for planning, and the requirements
are different compared with those of standard diagnostic imaging. In
addition, many applicators are available for use in BT treatment of
cervical cancer, and each must considered separately to determine
MR safety and to define the best imaging parameters. Starting and
supporting a robust gynecologic BT program includes implement-
ing imaging protocols that are helpful to both radiation oncologists
and diagnostic radiologists. By becoming more familiar with this
treatment modality and the logistics of imaging patients undergoing
BT, radiologists can provide imaging support for colleagues in the
radiation oncology department and better care for patients.
©
RSNA, 2018 • radiographics.rsna.org
Thomas Sullivan, MD
Joseph H. Yacoub, MD
Matthew M. Harkenrider, MD
William Small, Jr, MD
Murat Surucu, PhD
Steven M. Shea, PhD
Abbreviations: BT = brachytherapy, ESTRO =
European Society for Radiotherapy and Oncol-
ogy, FIGO = International Federation of Gy-
necology and Obstetrics, FSE = fast spin echo,
GEC = Groupe Européen de Curiethérapie,
GRE = gradient echo, HDR = high dose rate,
3D = three dimensional
RadioGraphics 2018; 38:932–944
https://doi.org/10.1148/rg.2018170033
Content Codes:
1
From the Departments of Radiology (T.S.,
J.H.Y., S.M.S.) and Radiation Oncology
(M.M.H., W.S., M.S.), Loyola University Chi-
cago, Stritch School of Medicine, Health Sci-
ences Division, 2160 S 1st Ave, Maywood, IL
60153. Presented as an education exhibit at the
2016 RSNA Annual Meeting. Received March
6; revision requested August 25 and received
October 6; accepted October 13. For this jour-
nal-based SA-CME activity, the author W.S. has
provided disclosures (see end of article); all other
authors, the editor, and the reviewers have dis-
closed no relevant relationships. Address corre-
spondence to S.M.S. (e-mail: stshea@lumc.edu).
©
RSNA, 2018
After completing this journal-based SA-CME
activity, participants will be able to:
■ Explain the role of MR imaging in cer-
vical BT.
■ Implement imaging protocols helpful
for both radiation oncologists and diag-
nostic radiologists.
■ Assess a properly placed applicator,
identify hardware, and interpret a BT
planning MR imaging study.
See www.rsna.org/education/search/RG.
SA-CME LEARNING OBJECTIVES
Introduction
Although the incidence of cervical cancer has declined significantly
in the last 40 years (primarily because of improved screening), nearly
12 000 new cases are diagnosed every year (1). Cancers of the cervix
are staged by using the International Federation of Gynecology and
Obstetrics (FIGO) staging system for prognosis and epidemiologic
reporting (2) (Table 1).
Cervical cancer treatment plans are tailored to each patient on the
basis of many factors, including tumor size, local extent, and nodal
status. Brachytherapy (BT) is an important part of an increasingly
standardized treatment plan. Typically, this plan also includes an ini-
tial course of platinum-based chemotherapy and external-beam ra-
diation therapy. BT is offered routinely after external-beam radiation
therapy for all stages of cervical cancer for which definitive nonsurgi-
cal treatment is indicated. This change is attributed to the emergence
of evidence of prolonged survival when both radiation therapy mo-
dalities (external-beam radiation therapy and high-dose-rate [HDR]
BT) are combined with cisplatin-based chemotherapy (3).
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