This article is protected by copyright. All rights reserved Editorial Acrosomal alkalization triggers Ca 2+ release and acrosome reaction in mammalian spermatozoa. † Running head: Ca 2+ channel blockers alkalize the acrosome triggering AR Julio C. Chávez 1 , José L. De la Vega-Beltrán 1 , Omar José 1 , Paulina Torres 1 , Takuya Nishigaki 1 , Claudia L. Treviño 1 and Alberto Darszon 1 * 1 Departamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad # 2001. Col. Chamilpa, Cuernavaca Morelos, CP 62210, México. *Correspondence to: darszon@ibt.unam.mx † This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jcp.26262] Additional Supporting Information may be found in the online version of this article. Received 20 May 2017; Revised 8 October 2017; Accepted 12 October 2017 Journal of Cellular Physiology This article is protected by copyright. All rights reserved DOI 10.1002/jcp.26262