Available online at www.ijpsdr.com 160 International Journal of Pharmaceutical Sciences and Drug Research 2017; 9(4): 160-168 Research Article ISSN: 0975-248X CODEN (USA): IJPSPP A Novel Technique to Enhance Dissolution Rate of Cilnidipine Using Liquisolid Compact & Wet Granulation Vinod Valjibhai Siju 1* , Moinuddin Soniwala 2 , Swati Nagar 1 1 School of Pharmacy, RK University, Rajkot - 360 020, Gujarat, India 2 B. K. Mody Government Pharmacy College, Rajkot - 360 003, Gujarat, India Copyright © 2017 Vinod Valjibhai Siju et al. This is an open access article distributed under the terms of the Creative Commons Attribution- NonCommercial-ShareAlike 4.0 International License which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. ABSTRACT The main objective of the work was to improve the dissolution rate of the drug, Cilnidipine (CLD) by using the liquisolid compact technique and wet granulation. Cilnidipine drug is poorly soluble in water and it’s highly soluble in higher pH. In this study drug is solubilize in tween 80 and sodium hydroxide and meglumine solution. And then drug solution binding on Pearlitol SD 200. PVP K30 used as a binder and crospovidone used as a disintegrant. Sodium hydroxide and meglumine used as a buffering agent for basic media preparation. The drug release rates of tablets which prepared by liquisolid compact have higher solubility and dissolution than conventional tablets. Keywords: Liquisolid compact, Cilnidipine, Tween 80, Pearlitol SD 200, Liquid load factor. DOI: 10.25004/IJPSDR.2017.090402 Int. J. Pharm. Sci. Drug Res. 2017; 9(4): 160-168 *Corresponding author: Mr. Vinod Valjibhai Siju Address: School of Pharmacy, RK University, Rajkot - 360 020, Gujarat, India E-mail : vinod.siju@gmail.com Relevant conflicts of interest/financial disclosures: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Received: 01 February, 2017; Revised: 06 June, 2017; Accepted: 14 June 2017; Published: 24 July 2017 INTRODUCTION The design of liquid solid compact with wet granulation requires physical and chemical compatibility with the excipients and API. Solubility and dissolution directly link to the bioavailability of API. Various approaches use to increase dissolution and bioavailability of the API. Liquisolid compact is a promising approach to enhance solubility and dissolution rate. In the present study solubility and dissolution of the API was increases by wetting the API with nonvolatile solvent. And wet granulation with the API + solvent media on the carrier and coating material which is simple wet granulation process. Meglumine and NaOH used as a buffering agent to dissolve an API in a nonvolatile solvent. The liquisolid technique was given by Spireas, in which liquid convert into a free flowing, powder by simple blending with carrier and coating material. Liquid portion is liquid drug or a liquid concentrate is added in to carrier material which is a diluent solvent mainly a PG, PEG and glycerin. [1] As a addition of liquid