Research Article http:// injec.aipni-ainec.org/index.php/INJEC/ index | 34 Ice Septriani Saragih 1 , Friska Sri Handayani BR Ginting 1 , Rumbun Sirait 1 Abstract Introduction: Coronavirus (COVID-19) is a problem that is being widely recognized and occurs in more than 200 countries in the world. The increase in cases has a negative impact on aspects of human life, which can cause anxiety. The purpose of this study was to analyze the effect of positive self-talk on the anxiety of COVID-19 patients. Methods: The population in this study were all COVID-19 patients at Adam Malik Hospital Medan with a total sample of 70 people. The sampling technique is non-probability sampling with a purposive sampling with the inclusion criteria in this study of patients with COVID-19 who were hospitalized with moderate degrees, patients who were cooperative and able to follow the instructions of the researcher. The research design was quasi-experimental and the data analysis used was paired t-test and independent t-test with the p-value <0.05. Result: The results showed that there was anxiety before and after the action was taken between the control group and the intervention group (p=0.000, <0.005). Based on the independent t-test, it showed that there was a positive effect of self-talk on the anxiety of COVID-19 patients before and before the action was taken (p = 0.000, <0.005). Conclusion: Therefore, these results indicate that positive self-talk is effective in reducing anxiety levels in COVID-19 patients. This intervention can be used as an alternative in nursing services to help reduce anxiety levels Keywords: Positive self-talk, anxiety, COVID-19 patients 1 Sekolah Tinggi Ilmu Kesehatan Santa Elisabeth Medan, Indonesia Corresponding Author Ice Septriani Saragih STIKES Santa Elisabeth Medan, Indonesia Email: iceseptriani.saragih@gmail.com EFFECT OF POSITIVE SELF- TALK ON ANXIETY AMONG PATIENTS WITH COVID-19 Indonesian Nursing Journal of Education and Clinic (INJEC) IN PRESS Volume 7 Issue 1, Juni 2022 DOI: 10.24990/injec.v7i1.447 injec.aipni-ainec.org/index.php/INJEC/index Received : 2021-10-30 Accepted : 2022-05-19 The Association of Indonesian Nurse Education Center (AINEC)