450 1680 Board #25 May 28, 2:00 PM - 3:30 PM The Effects of Resistance Training on Serum Visfatin and Muscle Damage in Healthy Young Adults Paul F. Mellick. University of St. Thomas, St Paul, MN. Email: mell0159@stthomas.edu (No relationships reported) Previous literature has shown plasma visfatin to act as an insulin-sensitizer, marker of inflammation, and metabolic enzyme. The response of serum visfatin to exercise is widely debated, and research regarding training protocols (especially resistance training) is lacking. Furthermore, its connection to exercise-induced muscle damage and inflammation is not fully understood. PURPOSE: To determine the effects of 4 weeks of resistance training on serum visfatin, IL-6, and plasma myoglobin in healthy, untrained young adults. METHODS: Seven apparently healthy, untrained, sedentary subjects (4 female, 3 male; Age = 20.09 ± 1.38 yrs; Ht = 167.64 ± 9.34 cm; Wt = 84.61 ± 36.80; BF = 27.73 ± 9.25%) took part in a 4-week resistance-training protocol. The protocol included five lifts involving major muscle groups with 3 sets of 8 repetitions done on 3 non-consecutive days each week with resistance increasing throughout. Blood was drawn prior to the start of training, and at the begging of each week of training. Plasma myoglobin and serum IL-6 and visfatin were assessed. Body fat percentage, lean mass, and fat mass were also determined prior to and after training using a bod pod. RESULTS: Serum IL-6 was not statistically different after 4 weeks of resistance training (p = 0.448). While there was no statistically significant difference for myoglobin or visfatin, (p = 0.454, p = 0.498, respectively), there was a trend of plasma myoglobin (176.8 ± 137.3 vs 454.6 ± 411.3 ng/ml) and serum visfatin (7.7237 ± 7.201 vs 14.786 ± 12.140 ng/ml) to increase after one week of training, and return to baseline by week 3. Body fat percentage, lean mass, and fat mass were not significantly affected by 4 weeks of resistance training. Finally, plasma myoglobin and serum visfatin were not significantly correlated (r2 = 0.3249, p = 0.2359). CONCLUSIONS: Four weeks of training did not significantly affect plasma myoglobin, serum visfatin, or IL-6. Although no statistical significance was found, there was a trend for muscle damage and serum visfatin to immediately increase with resistance training. Further research is needed regarding the role of visfatin in resistance training adaptations. 1681 Board #26 May 28, 2:00 PM - 3:30 PM The Effect of Exercise With or Without Metformin on Glucose Profiles in Type 2 Diabetes. Étienne Myette-Côté, Tasuku Terada, Normand G. Boulé. University of Alberta, Edmonton, Alberta, AB, Canada. (Sponsor: Darren DeLorey, FACSM) Email: myettect@ualberta.ca (No relationships reported) The glucose lowering effect of exercise is one of the most well documented finding in diabetes. However, recent studies suggest that this effect may be impaired when people with type 2 diabetes (T2D) are treated with metformin (MET). PURPOSE: 1- to confirm the previously observed increase in postprandial glucose immediately after exercise in T2D individuals treated with MET, 2- to determine how long the increased glucose persists, 3- to examine if skipping a dose of MET before or after exercise could help further improve glycemic control. METHODS: People with T2D taking MET were recruited. After a baseline assessment that included a graded exercise test, participants were assigned to randomly complete four experimental conditions: 1- morning and evening MET doses without exercise (M-M), 2- morning and evening MET doses with exercise (M-Ex-M), 3- exercise with evening MET dose only (Ex-M) and 4- morning MET dose only with exercise (M-Ex). Exercise consisted of walking continuously for 50 minutes at a moderate intensity starting at 11AM on the first day of the 72 hours experimental conditions. Standardized breakfasts, lunch and dinners were provided on the first day. Glucose profiles were assessed by continuous glucose monitoring. RESULTS: 10 participants with a mean (SD) age of 60(11)yr and a body mass index of 29.5(4.7)kg/m2 completed all four conditions. The 55-mins exercise significantly lowered glucose concentrations in every condition (respectively -2.8±3.0, -2.3±1.8, -2.4±2.4 mmol/L, all p<0.02). Compared to M-M, M-Ex-M didn’t improve daily mean glucose concentrations (dMEAN) (7.2±1.3 vs 7.0±1.4 mmol/L, p=0.32), fasting (6.6 ± 1.1 vs 6.8 ± 1.4 mmol/L, p=0.69), mean amplitude of glycemic excursion (MAGE) (3.1±1.5 vs 3.6±1.4 mmol/L, p=0.11) and deteriorated the average 2-hrs incremental postprandial area under the curve (I-pAUC) (153±39 vs 238±38 mmol/L/min, p<0.01). M-Ex (7.5 ± 1.6, p<0.05), but not Ex-M (7.5 ± 1.5, p=0.08) increased dMEAN compare to M-Ex-M. There were no differences among the three exercise conditions for fasting, MAGE and I-pAUC. CONCLUSION: The addition of exercise to MET led to an increase in postprandial glucose without increasing dMEAN glucose concentrations. Removing a MET dose before/after exercise did not attenuate this negative effect and even tended to worsen it. 1682 Board #27 May 28, 2:00 PM - 3:30 PM Eating Habits And Physical Exercise In Cancer Survivors Lisa Sequi, Cristian Petri, Gabriele Mascherini, Lorenzo Francini, Fabio Buralli, Maira Marques, Laura Stefani, Giorgio Galanti. Sport Medicine Department, Florence, Italy. Email: gabriele.mascherini@unifi.it (No relationships reported) PURPOSE: Healthy eating habits and active lifestyle have been shown to reduce mortality in not communicable chronic disease also in secondary prevention. The purpose was to assess and correct eating habits and physical exercise in overweight cancer survivors, to help them integrate back into normal life, improve their life quality and potentially improve their long-term survival chances. METHODS: 26 breast and colon overweight cancer survivors (from 41 to 75 ys, height 164±9 cm) were enrolled on a physical exercise program. On the first visit (T0), weight, body mass index (BMI), waist and hip circumferences, skinfold for estimation of fat mass and Bio Impedance Analysis (BIA) for hydration status were assessed. To each subject was given a food diary, to assess his eating habits. This approach consisted to correct wrong eating habits. After a week, they received personal advice on nutritional issues on the basis of the American Cancer Society’s Guidelines. Statistical analysis was performed with ANOVA test. RESULTS: From the analysis of food diaries, it emerges that fat and sodium consumption was high with low intake of fruits and vegetables. After having changed their eating habits, the following results were observed: - after 6 months (T6) the anthropometrics and hydration parameters showed a variation (weight T0: 73.28±16.11, T6: 72.10±15.00 kg p<0.01; total water T0: 50.94±6.51, T6:51.78±7.51 % p<0.05; extra-cellular water T0: 47.78± 4.70, T6: 47.98±4.90 % p<0.01); - after 12 months (T12) the program had a significant effect (weight T0: 73.28±16.11, T12: 71.85±14.78 kg p<0.02, BMI T0: 27.38±6.51, T12: 26.86±6.10 kg/m2 p<0.05; waist circumference T0: 87.96±15.21, T12: 86.38±13.16 cm p<0.05). CONCLUSIONS: In this population of overweight cancer survivors, findings suggest the importance of nutritional advice along with physical exercise, to improve nutritional status and body composition. Variation in weight, BMI, waist circumference, total water and extra-cellular water, are been useful for reducing risk factors in not communicable chronic disease. 1683 Board #28 May 28, 2:00 PM - 3:30 PM Metformin May Blunt Beneficial Effects Of Exercise Training On Cancer-related Biomarkers In Women With Prediabetes Richard Viskochil 1 , Jaime Laurin 1 , Steven K. Malin 2 , Jennifer M. Blankenship 1 , Barry Braun, FACSM 3 . 1 University of Massachusetts, Amherst, MA. 2 University of Virginia, Charlottesville, VA. 3 Colorado State University, Fort Collins, CO. (Sponsor: Barry Braun, PhD, FACSM) Email: rviskoch@kin.umass.edu (No relationships reported) Copyright © 2015 by the American College of Sports Medicine. Unauthorized reproduction of this article is prohibited.