1 SUPPLEMENTARY MATERIAL Thiotagetin A, a new cytotoxic thiophene from Tagetes minuta Sabrin R.M. Ibrahim a,b,* and Gamal A. Mohamed c,d a Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al Madinah Al Munawwarah 30078, Saudi Arabia; b Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt; c Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; d Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch 71524, Assiut, Egypt. * Corresponding Author. Tel.: +966 581183034. E-mail addresses: sribrahim@taibahu.edu.sa ; sabrinshaur@gmail.com .