Case Report Two Cases of Post-Traumatic Mucormycosis due to Mucor circinelloides: Salvage Therapy with a Combination of Adjunctive Therapies A. De Paepe, 1 K. Dams , 1 D. Robert, 1 R. Jacobs, 1 G. L. Ten Kate , 2 S. Van Ierssel, 2 H. Jansens, 3 M. Lammens, 4 A. Van Beeck, 5 and P. G. Jorens 1 1 Departments of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium 2 Departments of Infectious Diseases, Antwerp University Hospital, University of Antwerp, Edegem, Belgium 3 Departments of Microbiology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium 4 Departments of Pathology, Antwerp University Hospital, University of Antwerp, Edegem, Belgium 5 Departments of Orthopaedics, Antwerp University Hospital, University of Antwerp, Edegem, Belgium Correspondence should be addressed to P. G. Jorens; philippe.jorens@uza.be Received 3 February 2022; Accepted 6 April 2022; Published 4 May 2022 Academic Editor: Fariborz Mansour-Ghanaei Copyright © 2022 A. De Paepe et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mucormycosis is a rare, emerging angioinvasive infection caused by ubiquitous filamentous fungi. In recent decades, an increase in cutaneous or post-traumatic mucormycosis has been reported. We describe two cases of post-traumatic wound infections with Mucor circinelloides, a mucor species only rarely reported as a cause of post-traumatic mucormycosis. Often considered lethal, management required a combination of medical and surgical therapies to achieve a favorable outcome in both cases. 1. Introduction Mucormycosis is an aggressive fungal disease caused by members of the phylum Glomeromycota, subphyla Mucor- omycotina and Entomophtoromycotina (formerly phylum Zygomycota, orders of Mucorales and Entomophthorales) [1–3]. Most frequently, mucormycosis is a disease of an im- munocompromised host, either due to hematological malig- nancy, hematopoietic stem cell or solid organ transplantation, or poorly controlled diabetes mellitus, especially in the presence of diabetic ketoacidosis [4]. More recently, COVID-19 and the associated treatment with corticosteroids were also identified as risk factors for the development of mucormycosis [5]. e disease has various presentations: rhino-orbito-cerebral, pul- monary, cutaneous, gastrointestinal, or disseminated disease. Cutaneous disease, although rare, also occurs in immuno- competent hosts, especially following trauma [6]. In this report, we describe two cases of post-traumatic mucormycosis due to infection with Mucor circinelloides in two road traffic accident victims. 2. Case 1 and 2 In the first case, the proven invasive fungal disease was confirmed by histopathology (presence of hyphae and ne- crotic tissue), whereas in the second case diagnosis was based on the clinical picture and tissue culture of bone and muscle. Histopathology showed muscle necrosis without the pres- ence of hyphae [7]. e cultures were sent to the national reference center for invasive fungal disease for identification (matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) and mass spectrometry identification (MSI) platform) and susceptibility testing (E-test). is mucor species has rarely been detected in humans after trauma or in cutaneous infections. Effective management required re- peated surgical debridement, conventional antifungal therapy, and a combination of adjunctive therapies. 2.1. Case 1 Presentation. A 20-year-old, previously healthy male patient suffered from a road traffic accident. He was hit by a truck with a subsequent fall off a bridge and landed in Hindawi Case Reports in Infectious Diseases Volume 2022, Article ID 4949426, 8 pages https://doi.org/10.1155/2022/4949426