Journal of Pharmaceutical Negative Results ¦ Volume 13 ¦ Special Issue 6 ¦ 2022 2826 DEVELOPMENT OF SMART METERED-DOSE INHALERS FOR SELF MEDICATION PURPOSES (DRUG-DEVICE-SOFTWARE) Dhiraj Behl 1 , Tanveer Naved 1 , Harikesh Kalonia 1 , Manu Babbar 2 1 Center for Drug and Regulatory Affair, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India 2 Project Leader, Regulatory Affairs Department, Medicamen Biotech Limited, New Delhi, India Email: dhiraj1987@gmail.com DOI: 10.47750/pnr.2022.13.S06.363 The Internet of Things (IoT) is a network of internet-enabled accessory containing integrated sensors and actuators for external communication. The numeral of devices attached to the Internet is rising at a fast rate because of their extensive uses in several fields, like health care farming, sports, and patient safety. The IoT is a concept that considers the persistent presence of wireless, cable, interactive, communicable and collaborative things and objects and that allows new services to achieve common goals, such as diagnostic of symptoms of disease, treatment, a patient cure. The internet offers various healthcare applications from remote monitoring to intelligent sensors and the integration of medical devices. Healthcare IoT can also increase patient involvement and happiness by allowing patients to spend more time with their physicians. A promising technology is now made of IoT-enabled wearable sensors that allow continuous wireless monitoring of critical physiological variables. The focus here was on developing a combination product that was the development of smart metered- dose inhalers, one of the most visible areas of digital pharmaceutical involvement by studying related work. This digital technology was developed in order to improve lung diseases like asthma and COPD and to improve the efficiency of the prescribed media. These monitoring devices connect themselves to the inhaler of your user and should ideally be able to monitor compliance, record the accuracy of every dose, retain data, and not allow access to data to download to the computer for dosing regimen by doctors. Keywords: The Internet of Things (IoT), Healthcare, Smart metered-dose inhalers, Drug-Device, Drug-Device-Software, Combination Products. 1.INTRODUCTION Current breathlessness and wheezing episodes, which vary in intensity and frequency from person to human, are chronic illnesses. Connected gadgets for health and fitness monitoring are widely used by customers[1]. In recent years, patients, using wearables and apps, have expanded the use of digital health management tools to monitor their health and access their data[2]. Medication adherence is one of the biggest hurdles to improving patients' health. Various approaches, from professional education and clinic and pharmacist guidance to family assistance, have been explored[3]. Regrettably, everyone has been complicated, time-consuming, and expensive and has produced little returns[4]. Supervision of medicine usage, particularly asthma, for respiratory disorders Smart inhalers has been acknowledged as a new way to improving adherence[5]. Asthmatics are managed or quickly relieved with a metered dosage inhaler (MDI). Inadequate usage of the inhaler can reduce the efficacy of the device and result in more treatment expenses for the patient by administering an inappropriate dose[6]. The IoT connects actual items to the Internet, allowing information to be exchanged and acquired. Machine learning, sensors, embedded systems, and real-time analysis, have all grown in or from the IoT. It's all about the smart healthcare knowledge and other accessory that are connected to the Internet through telecommunication links. In order to do the desired work, smart devices may acquire and exchange data in everyday life[7]. The IoT is a recent issue in the tech industry, guideline organizations, and architect clusters, and it's creating caption in both the trade and general press. This technology may be found in a broad range of networked devices, systems, and sensors that take use of approach in processing capacity, transistors downsizing, and network linkages to provide formerly elusive features. Many symposia, papers, and broad cast belief analyze and answer the possible implications of the "Internet of Things revolution," from new industry prospects and business models to technical interoperability, security and concealment problems[8].