Accepted Manuscript Patients with severe orthohantavirus cardiopulmonary syndrome due to Sin Nombre Virus infection have increased circulating extracellular vesicle tissue factor and an activated coagulation system Kohei Tatsumi, Yohei Hisada, Anne-Marie Fors Connolly, Tione Buranda, Nigel Mackman PII: S0049-3848(19)30227-0 DOI: https://doi.org/10.1016/j.thromres.2019.04.032 Reference: TR 7359 To appear in: Thrombosis Research Received date: 13 February 2019 Revised date: 25 March 2019 Accepted date: 30 April 2019 Please cite this article as: K. Tatsumi, Y. Hisada, A.-M.F. Connolly, et al., Patients with severe orthohantavirus cardiopulmonary syndrome due to Sin Nombre Virus infection have increased circulating extracellular vesicle tissue factor and an activated coagulation system, Thrombosis Research, https://doi.org/10.1016/j.thromres.2019.04.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.