Accepted Manuscript Title: Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches Authors: Silvano Esposito, Giuseppe De Simone, Giovanni Boccia, Francesco De Caro, Pasquale Pagliano PII: S2213-7165(17)30135-2 DOI: http://dx.doi.org/doi:10.1016/j.jgar.2017.06.013 Reference: JGAR 459 To appear in: Received date: 25-4-2017 Revised date: 20-6-2017 Accepted date: 25-6-2017 Please cite this article as: Silvano Esposito, Giuseppe De Simone, Giovanni Boccia, Francesco De Caro, Pasquale Pagliano, Sepsis and septic shock: New definitions, new diagnostic and therapeutic approaches (2010), http://dx.doi.org/10.1016/j.jgar.2017.06.013 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.