Supporting Information S1 Supporting Information Discovery and Optimization of Quinazolinonepyrrolopyrrolones as Potent and Orally Bioavailable panPim Kinase Inhibitors Liping H. Pettus,* Kristin L. Andrews, Shon K. Booker, Jie Chen, Victor J. Cee, Frank Chavez Jr., Yuping Chen, Heather Eastwood, Nadia Guerrero, Bradley Herberich, Dean Hickman; Brian A. Lanman, Jimmy Laszlo III, Matthew R. Lee, J. Russell Lipford, Bethany Mattson, Christopher Mohr, Yen Nguyen, Mark H. Norman, David Powers, Anthony B. Reed, Karen Rex, Christine Sastri, Nuria Tamayo, Paul Wang, Jeffrey T. Winston, Bin Wu, Tian Wu, Ryan P. Wurz, Yang Xu, Yihong Zhou, Andrew S. Tasker, and HuiLing Wang Table SI1. Statistical analysis of data for compounds 126 S2 Figure SI1. Mouse body weight and TGI data in KMS12 BM xenograft with 17 S7 PDB: 5IPJ Crystal structure of 17 in complex with human Pim1 kinase S8 Table SI2. KINOMEscan data of 17 (at 1 M) against 100 kinases S12