Journal Pre-proof Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method Erin C. Berthold, Shyam H. Kamble, Kanumuri S. Raju, Tamara I. King, Raluca Popa, Abhisheak Sharma, Francisco Le´ on, Bonnie A. Avery, Lance R. McMahon, Christopher R. McCurdy PII: S0731-7085(20)31664-2 DOI: https://doi.org/10.1016/j.jpba.2020.113778 Reference: PBA 113778 To appear in: Journal of Pharmaceutical and Biomedical Analysis Received Date: 27 July 2020 Revised Date: 12 November 2020 Accepted Date: 13 November 2020 Please cite this article as: Berthold EC, Kamble SH, Raju KS, King TI, Popa R, Sharma A, Le´ on F, Avery BA, McMahon LR, McCurdy CR, Preclinical pharmacokinetic study of speciociliatine, a kratom alkaloid, in rats using an UPLC-MS/MS method, Journal of Pharmaceutical and Biomedical Analysis (2020), doi: https://doi.org/10.1016/j.jpba.2020.113778 This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier.